How many cell types are in the kidney and what do they do?

MS Balzer, T Rohacs, K Susztak - Annual review of physiology, 2022 - annualreviews.org
… and genetic cell type definition with remarkable precision. Here, we discuss how each
kidney cell type has specialized to achieve this complex function, how an individual cell's gene …

Mapping the human kidney using single-cell genomics

F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
cells. Insights into the phenotypic diversity of kidney endothelial and kidney-resident immune
cells has been reviewed elsewhere 34,35 , and so here we focus mainly on the cellular

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

X Sheng, Y Guan, Z Ma, J Wu, H Liu, C Qiu, S Vitale… - Nature …, 2021 - nature.com
… To estimate the sharing of cell type eQTL(ci)s across different cell types in each kidney
compartment, we adopted a multivariate adaptive shrinkage method (mash) 41 and followed the …

Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response

H Wu, AF Malone, EL Donnelly, Y Kirita… - Journal of the …, 2018 - journals.lww.com
… -seq analysis of a single human kidney allograft biopsy. We used … cell types and novel cell
states within endothelium. We compared tubular cell transcriptomes with healthy adult kidney

[PDF][PDF] Cell-type-specific gene programs of the normal human nephron define kidney cancer subtypes

D Lindgren, P Eriksson, K Krawczyk, H Nilsson… - Cell reports, 2017 - cell.com
… of the transcriptional landscape of normal human kidneys and how these may be reflected
cell types of the nephron and use these results to define the histological origin for kidney

[HTML][HTML] Single-cell RNA sequencing of human kidney

J Liao, Z Yu, Y Chen, M Bao, C Zou, H Zhang, D Liu… - Scientific data, 2020 - nature.com
… -specific, especially renal tubular cells. To investigate the classification and … the human
kidney, we rapidly obtained a single-cell suspension of the kidney and conducted single-cell RNA …

[HTML][HTML] An atlas of healthy and injured cell states and niches in the human kidney

BB Lake, R Menon, S Winfree, Q Hu, R Melo Ferreira… - Nature, 2023 - nature.com
… complexity for all cell types along the depth of the kidney from the … human kidney cell types
with associated biomarkers (Methods and Supplementary Tables 5−8). This includes cell type

(Re) Building a kidney

L Oxburgh, TJ Carroll, O Cleaver… - Journal of the …, 2017 - journals.lww.com
human kidney cell types to determine which cellular … of human induced pluripotent stem
cells (iPSCs), (2) produce and characterize human kidney progenitor cells from pluripotent cells

In situ classification of cell types in human kidney tissue using 3D nuclear staining

A Woloshuk, S Khochare, AF Almulhim… - Cytometry Part …, 2021 - Wiley Online Library
… a cell type label. We then devised various supervised machine learning approaches for kidney
cell … allowed in situ visualization of cell type classifications in kidney tissue. In conclusion, …

[HTML][HTML] The chromatin landscape of healthy and injured cell types in the human kidney

DL Gisch, M Brennan, BB Lake, J Basta… - Nature …, 2024 - nature.com
… the cell type-specific open chromatin signature across the kidney’s diverse range of cell
types. … The multiome atlas yielded 72 distinct cell types based on a pre-existing human kidney