… In this report, we extend the kidney development atlas to single cell resolution. At several …
of cells that will contribute to the stromal, nephron and vascular components of the kidney. …

… are important for kidney induction and subsequent development. Another caveat in these
rat experiments is the use of isolated mesenchyme that has been dissected free from ureteric …

… fetal kidneys remains limited. To address the key features of human fetal kidney development,
we applied single-cell RNA sequencing (scRNA-seq) to >3,000 renal cells spanning …

… Herein, using cell sorting, RNA sequencing, in vitro studies … kidney development and
tumorigenesis; In nephrogenesis, NCAM1 + CD133 − marks SIX2 + multipotent renal stem cells …

… In our original approach, we developed a ureteric bud-derived cell line [5] and assayed
fractions for their potential to induce epithelialization in metanephric mesenchyme. This led to the …

… in ES cells to study the role of R-cadherin during kidney … ), we were unable to study kidney
development in R-cadherin −/− … , and to our surprise, kidney development was not affected to a …

… pression profiles of the major elements of kidney development. This data set represents the
… .5 and E15.5 kidneys (metanephroi) were rapidly dissected from embryos and stored briefly …

… cells have provided most of our new insights into the classic models of kidney development.
… morphogenesis is increasing and has allowed for a genetic dissection of key steps in the …

… illumination, implemented on a dissecting microscope and combined with reconstruction of
… and disturbed kidney development in zebrafish. In particular, the GFP-positive cells in wt1a …

… the developing kidney. Here, we document expression of the adult stem cell marker Lgr5
in the developing kidney and assess the stem/progenitor identity of Lgr5 +ve cells via in vivo …