Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

…, International IBD Genetics Consortium (IIBDGC)… - Nature, 2012 - nature.com
… c, GRAIL network for all genes with GRAIL P < 0.05. Genes included in our previous GRAIL
… blue, newly connected genes in previously identified loci in dark blue, and genes from newly …

Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut …

S Doms, H Fokt, MC Rühlemann, CJ Chung… - Elife, 2022 - elifesciences.org
… To gain further insight into the genetic architecture of microbial trait abundances, we …
Importantly, our results also help to describe general features of the genetic architecture of bacterial …

A behavioral model for mapping the genetic architecture of gut-microbiota networks

L Jiang, X Liu, X He, Y Jin, Y Cao, X Zhan… - … microbes, 2021 - Taylor & Francis
… and quantifying the networks of various interaction types for microbial communities. We
map the host genetic architecture of how microbes interact and work together to determine …

[HTML][HTML] Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes

L Brettner, WC Ho, K Schmidlin, S Apodaca… - … opinion in genetics & …, 2022 - Elsevier
… Here, we discuss challenges and recent advances in understanding the genetic architecture
of adaptation, many of which also apply more generally to understanding genotype-…

Housing helpful invaders: the evolutionary and molecular architecture underlying plant root-mutualist microbe interactions

B Lagunas, P Schäfer, ML Gifford - Journal of Experimental …, 2015 - academic.oup.com
… to discuss aspects of the architecture connecting mutualistic plant–microbe interactions. …
The natural abundance of this type of plant–microbe interaction is generally unknown since they …

Whose trait is it anyways? Coevolution of joint phenotypes and genetic architecture in mutualisms

AM O'Brien, CN Jack, ML Friesen… - Proceedings of the …, 2021 - royalsocietypublishing.org
… correlations could leverage quantitative genetic theory for phenotypes influenced by
interacting conspecifics [13]. Lastly, our model assumes one microbe interacts with each host, but …

The genetic architecture of resistance

ND Young - Current opinion in plant biology, 2000 - Elsevier
… in gene families other than R genes? If so, detailed studies of the genome architecture and
molecular evolution of plant R genes could … beyond the field of plant–microbe interactions. …

Genetic architecture of heritable leaf microbes

JA Boyle, ME Frederickson, JR Stinchcombe - bioRxiv, 2024 - biorxiv.org
… experience selection due to conditions on the leaf surface and microbe-microbe interactions
… Host genetics play a role in the leaf microbiome; the similarity of leaf microbiomes across 56 …

Large-scale genomics unveils the genetic architecture of psychiatric disorders

J Gratten, NR Wray, MC Keller, PM Visscher - Nature neuroscience, 2014 - nature.com
… involved in neurodevelopmental disorders is reviewed by Hoischen and Eichler 61 , so we
focus here on implications of these studies for genetic architecture, with a brief overview of …

[HTML][HTML] Bacterial Genetic Architecture of Ecological Interactions in Co-culture by GWAS-Taking Escherichia coli and Staphylococcus aureus as an Example

X He, Y Jin, M Ye, N Chen, J Zhu, J Wang… - Frontiers in …, 2017 - frontiersin.org
… Studies) to illustrate the genetic architecture of ecological interactions that take place in …
We reported 66 and 111 SNPs that were associated with interaction in E. coli and S. aureus, …