[HTML][HTML] The accessible chromatin landscape of the human genome

RE Thurman, E Rynes, R Humbert, J Vierstra… - Nature, 2012 - nature.com
… From examination of DNase I profiles across many cell types we observed that many
known cell-selective enhancers become DHSs synchronously with the appearance of …

[HTML][HTML] The chromatin landscape of healthy and injured cell types in the human kidney

DL Gisch, M Brennan, BB Lake, J Basta… - Nature …, 2024 - nature.com
Cell-type specific open chromatin in the reference cell state … data to better understand the
cell type-specific open chromatin signature across the kidney’s diverse range of cell types. The …

Engineering cell identity: establishing new gene regulatory and chromatin landscapes

C Guo, SA Morris - Current opinion in genetics & development, 2017 - Elsevier
chromatin landscape, considering how the mechanistic relationship between nuclear
organization and cell identity will be crucial to unlocking the full potential of cell fate engineering. …

A view of the chromatin landscape

LM Rapkin, DRP Anchel, R Li, DP Bazett-Jones - Micron, 2012 - Elsevier
cell nucleus. Moreover, the structure and location of genetic loci display cell type-specific …
the interdependence of chromatin structure and nuclear function in mammalian cells. In this …

The chromatin landscape of cellular senescence

SW Criscione, YV Teo, N Neretti - Trends in Genetics, 2016 - cell.com
… Senescent cells undergo dramatic alterations to their chromatin landscape that affect
genome … of the role of chromatin and chromosome organization in cellular senescence. …

Integrating and mining the chromatin landscape of cell-type specificity using self-organizing maps

A Mortazavi, S Pepke, C Jansen, GK Marinov… - Genome …, 2013 - genome.cshlp.org
… New candidate cell-type-specific enhancers were identified for multiple ENCODE cell types
in … We conclude that large SOMs trained on chromatin data from multiple cell types provide a …

[HTML][HTML] A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma

N Kourtis, Q Wang, B Wang, E Oswald, C Adler… - Nature cancer, 2022 - nature.com
… -cell assay technology for transposase-accessible chromatin … Through surveying the
chromatin landscapes of T cells of … , we observe cell-type-specific and tissue-specific chromatin

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

AT Satpathy, JM Granja, KE Yost, Y Qi, F Meschi… - Nature …, 2019 - nature.com
cells in two biological contexts. First, we mapped the single-cell chromatin accessibility
landscape of … humans, which revealed chromatin states of progenitor cells and the regulatory …

Cell identity bookmarking through heterogeneous chromatin landscape maintenance during the cell cycle

H Luo, Y Xi, W Li, J Li, Y Li, S Dong… - Human molecular …, 2017 - academic.oup.com
… polycomb-repressed chromatin played a role in repressing the irrelevant cell type-specific …
) marked the genes crucial for cell identity maintenance. Chromatin structure at NSRs and …

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

MI Love, MR Huska, M Jurk, R Schöpflin… - Nucleic acids …, 2017 - academic.oup.com
cell types than for cell type-specific target genes. Given that GR almost exclusively binds
accessible chromatin, we propose that cell type-… chromatin accessibility is typically cell type-…