… Other studies have shown that variability in the expression and/or binding of specific
transcription factors is highly correlated with heterogeneity of chromatin accessibility at associated …

… of transcriptional noise and bursts, their influence on cellular heterogeneity and their impact
on cellular fate. We … how ageing affects transcriptional processes and cellular heterogeneity. …

… We used Seurat to determine the cellular composition of our snRNA-seq samples, annotate
cells based on their transcriptional profiles, and inform our snATAC-seq analysis (Fig. 1a). …

… NK cells and KLRG1 + effector CD8 + T cells had greater activity in inflammation-promoting. …
of cellular heterogeneity in FHP, and highlight the indispensable role of cell subpopulations …

… previously appreciated, the extent of this cellular heterogeneity in the human thymus is not
well understood. Here we use single-cell RNA sequencing to comprehensively profile the …

… transcription and translation have inherent randomness based on the variables associated
with molecular recognition and other factors that govern cellular … causes transcriptional …

… in the transcriptional program of the cell [13, 17]. We envisage cellular TL heterogeneity within
… the cell encounters. As with the “quasi-species” defined for RNA viruses [75], this gives the …

… the 45-min IκBε transcription delay is optimal for generation of cellular variation in oscillation
… timing affects the cellular heterogeneity of NF-κB oscillations and the ability of single cells to …

… cellular heterogeneity, we developed a combinatorial indexing strategy to profile the
transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell … nearly 50,000 cells from …

… cells and found that the allelic DNA methylation state is dynamically switching, resulting in
cell-to-cell heterogeneity… between DNA methyltransferases and transcription factor binding on …