Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA
breaks are released. Substituents at the C-8 position increase activities of N-1-cyclopropyl …

When the lethal action of a C-8 methoxyl fluoroquinolone against clinical isolates of
Mycobacterium tuberculosis in liquid medium was measured, the compound was found to …

The increasing prevalence of antibiotic resistance among bacterial pathogens prompted a
microbiological study of fluoroquinolone structure-activity relationships with resistant …

Quinazolinediones (diones) are fluoroquinolone-like inhibitors of bacterial gyrase and DNA
topoisomerase IV. To assess activity against mycobacteria, C-8-methoxy dione derivatives …

Objectives: To examine the effect of first-line and second-line anti-tuberculosis agents on the
ability of fluoroquinolones to kill mycobacteria. Methods: A clinical isolate of Mycobacterium …

To characterize mechanisms of resistance to fluoroquinolones by Mycobacterium
tuberculosis, mutants of strain H37Ra were selected in vitro with ofloxacin. Their quinolone …

Fluoroquinolones are potent antibacterial agents that are being used as therapeutic agents
for the treatment of multidrug-resistant tuberculosis. To better understand fluoroquinolone …

We investigated the enzymatic efficiency and inhibition by quinolones of Mycobacterium
tuberculosis DNA gyrases carrying the previously described GyrA G88C mutation and the …

Mutant prevention concentration (MPC) has been proposed as a new measure of antibiotic
potency by which the ability to restrict selection of resistant mutants is evaluated. To …

Quinolones were examined for rapid lethal activity against Mycobacterium smegmatis in the
presence and absence of chloramphenicol, an inhibitor of protein synthesis. C-8 methoxy, C …