We characterized the role of catabolite control protein A (ccpA) in the physiology and
virulence of Streptococcus pneumoniae. S. pneumoniae has a large percentage of its …

ABSTRACT A spontaneous mutant of Streptococcus pneumoniae strain D39 exhibiting
elevated β-galactosidase activity was identified. We determined that the β-galactosidase …

Carbon catabolite repression (CCR) allows bacteria to alter metabolism in response to the
availability of specific sugar sources, and increasing evidence suggests that CCR is …

In Gram-positive bacteria, the transcriptional regulator CcpA is at the core of catabolite
control mechanisms. In the human pathogen Streptococcus pneumoniae, links between …

A 10.2-kb gene region was identified in the Streptococcus pneumoniae genome sequence
that contains eight genes involved in regulation and metabolism of raffinose. The genes rafR …

Background The catabolite control protein A (CcpA) is a member of the LacI/GalR family of
transcriptional regulators controlling carbon-metabolism pathways in low-GC Gram-positive …

Carbon catabolite protein A (CcpA) is known to function as a major regulator of gene
expression in different gram-positive organisms. Deletion of the ccpA homologue …

CcpA is the global mediator of carbon catabolite repression (CCR) in gram-positive bacteria,
and growing evidence from several pathogens, including the group A streptococcus (GAS) …

As part of a study of virulence gene regulation in Streptococcus pneumoniae, we have
identified a gene encoding a homologue of the staphylococcal catabolite control protein …

CcpA globally regulates transcription in response to carbohydrate availability in many gram-
positive bacteria, but its role in Streptococcus mutans remains enigmatic. Using the fructan …