Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in …

CF Deacon, MA Nauck, M Toft-Nielsen, L Pridal… - Diabetes, 1995 - Am Diabetes Assoc
To fate of exogenous glucagon-like peptide I (GLP-I)(7–36) amide was studied in
nondiabetic and type II diabetic subjects using a combination of high-pressure liquid …

Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans

C Ørskov, L Rabenhøj, A Wettergren, H Kofod… - Diabetes, 1994 - Am Diabetes Assoc
Using specific radioimmunoassays, we studied the occurrence of amidated and glycine-
extended glucagon-like peptide I (GLP-I) molecules in the human small intestine and …

Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM

J Dupre, MT Behme, IM Hramiak, P McFarlane… - Diabetes, 1995 - Am Diabetes Assoc
Effects of human glucagon-like peptide I (GLP-I)(7–36) amide were examined in volunteers
having insulin-dependent diabetes mellitus (IDDM) with residual C-peptide (CP) secretion …

Glucagonlike peptide I (7–37) actions on endocrine pancreas

GC Weir, S Mojsov, GK Hendrick, JF Habener - Diabetes, 1989 - Am Diabetes Assoc
Glucagonlike peptide I (7–37)[GLP-I-(7–37)], encoded with glucagon and glucagonlike
peptide II and intervening peptide II in the rat and human glucagon gene, is processed from …

The effect of glucagon-like peptide I (GLP-I) on glucose elimination in healthy subjects depends on the pancreatic glucoregulatory hormones

M Toft-Nielson, S Madsbad, JJ Holst - Diabetes, 1996 - Am Diabetes Assoc
Glucagon-like peptide I (GLP-I) decreases plasma glucose in type II diabetic patients and in
healthy subjects indirectly by stimulation of insulin and inhibition of glucagon secretion …

Biological effects and metabolic rates of glucagonlike peptide-1 7–36 amide and glucagonlike peptide-1 7–37 in healthy subjects are indistinguishable

C Ørskov, A Wettergren, JJ Holst - Diabetes, 1993 - Am Diabetes Assoc
The biological effects and the metabolism of the intestinal hormone glucagonlike peptide-1 7–
36 amide and glucagonlike peptide-1 7–37 were studied in normal healthy subjects. GLP-1 …

Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control …

JJ Meier, MA Nauck, D Kranz, JJ Holst, CF Deacon… - Diabetes, 2004 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) are important
factors in the pathogenesis of type 2 diabetes and have a promising therapeutic potential …

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

CF Deacon, AH Johnsen, JJ Holst - The Journal of Clinical …, 1995 - academic.oup.com
The metabolism of glucagon-like peptide-1 (GLP-1) has not been studied in detail, but it is
known to be rapidly cleared from the circulation. Measurement by RIA is hampered by the …

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients

MA Nauck, N Kleine, C Ørskov, JJ Holst, B Willms… - Diabetologia, 1993 - Springer
Summary Glucagon-like peptide 1 (GLP-1)(7-36 amide) is a physiological incretin hormone
that is released after nutrient intake from the lower gut and stimulates insulin secretion at …

Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects

T Vilsbøll, H Agersø, T Krarup… - The Journal of Clinical …, 2003 - academic.oup.com
We have previously shown that type 2 diabetic patients have decreased plasma
concentrations of glucagon-like peptide 1 (GLP-1) compared with healthy subjects after …