[HTML][HTML] Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

O Abani, A Abbas, F Abbas, M Abbas, S Abbasi… - The Lancet, 2022 - thelancet.com
Background Casirivimab and imdevimab are non-competing monoclonal antibodies that
bind to two different sites on the receptor binding domain of the SARS-CoV-2 spike …

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group, PW Horby… - Medrxiv, 2021 - medrxiv.org
Background REGEN-COV is a combination of 2 monoclonal antibodies (casirivimab and
imdevimab) that bind to two different sites on the receptor binding domain of the SARS-CoV …

[HTML][HTML] Casirivimab–Imdevimab treatment is associated with reduced rates of hospitalization among high-risk patients with mild to moderate coronavirus disease-19

RR Razonable, C Pawlowski, JC O'Horo, LL Arndt… - …, 2021 - thelancet.com
Background Real-world clinical data to support the use of casirivimab–imdevimab for the
treatment of outpatients with mild to moderate coronavirus disease-19 (COVID-19) is …

Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo …

GA Herman, MP O'Brien, E Forleo-Neto… - The Lancet Infectious …, 2022 - thelancet.com
Background There is an unmet need for COVID-19 prevention in patient populations who
have not mounted or are not expected to mount an adequate immune response to complete …

Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: A randomised, double-blind, phase 3 trial

TL Holland, AA Ginde, R Paredes… - The Lancet …, 2022 - thelancet.com
Background Tixagevimab–cilgavimab is a neutralising monoclonal antibody combination
hypothesised to improve outcomes for patients hospitalised with COVID-19. We aimed to …

Effect of subcutaneous casirivimab and imdevimab antibody combination vs placebo on development of symptomatic COVID-19 in early asymptomatic SARS-CoV-2 …

MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - Jama, 2022 - jamanetwork.com
Importance Easy-to-administer anti–SARS-CoV-2 treatments may be used to prevent
progression from asymptomatic infection to symptomatic disease and to reduce viral …

Association of subcutaneous or intravenous administration of casirivimab and imdevimab monoclonal antibodies with clinical outcomes in adults with COVID-19

EK McCreary, JR Bariola, RJ Wadas… - JAMA Network …, 2022 - jamanetwork.com
Importance Monoclonal antibody (mAb) treatment decreases hospitalization and death in
high-risk outpatients with mild to moderate COVID-19; however, only intravenous …

[HTML][HTML] Breakthrough COVID-19 and casirivimab-imdevimab treatment during a SARS-CoV-2 B1. 617.2 (Delta) surge

DM Bierle, R Ganesh, RR Razonable - Journal of Clinical Virology, 2021 - Elsevier
Introduction: The impact of vaccination and casirivimab-imdevimab monoclonal antibody
treatment on the clinical outcome of COVID-19 during a period of SARS-CoV-2 Delta surge …

Casirivimab and imdevimab for the treatment of hospitalized patients with COVID-19

S Somersan-Karakaya, E Mylonakis… - The Journal of …, 2023 - academic.oup.com
Background The open-label RECOVERY study reported improved survival in hospitalized,
SARS-CoV-2 seronegative patients treated with casirivimab and imdevimab (CAS+ IMD) …

[HTML][HTML] Casirivimab/imdevimab: first approval

ED Deeks - Drugs, 2021 - Springer
Abstract Casirivimab/imdevimab (Ronapreve™; REGEN-COV™) is a co-packaged
combination of two neutralizing immunoglobulin gamma 1 (IgG1) human monoclonal …