Although accumulating data have investigated the effect of SARS-CoV-2 mutations on
antibody neutralizing activity, less is known about T cell immunity. In this work, we found that …

Omicron BA. 1 variant can readily infect people with vaccine-induced or naturally acquired
SARS-CoV-2 immunity facilitated by escape from neutralizing antibodies. In contrast, T-cell …

Summary The SARS-CoV-2 Omicron variant (B. 1.1. 529) contains mutations that mediate
escape from antibody responses, although the extent to which these substitutions in spike …

SARS-CoV-2 variants that escape neutralization and potentially affect vaccine efficacy have
emerged. T cell responses play a role in protection from reinfection and severe disease, but …

Robust T cell responses have been associated with milder outcomes in many infections. T
cells also establish long-term memory pools and, as they are predominantly directed toward …

Importance The emergence of the highly contagious Omicron variant of SARS-CoV-2 and
the findings of a significantly reduced neutralizing potency of sera from convalescent or …

Introduction The prime-boost COVID-19 mRNA vaccination strategy has proven to be
effective against severe COVID-19 disease and death. However, concerns have been raised …

Summary The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations that
contribute to escape from the neutralizing antibody responses, and reducing vaccine …

Abstract The Omicron SARS-CoV-2 variant contains 34 mutations in the spike gene likely
impacting protective efficacy from vaccines. We evaluated the potential impact of these …

Several COVID-19 vaccines are approved to prevent severe disease outcome after SARS-
CoV-2 infection. Whereas induction and functionality of antiviral antibody response are …