Computational biomedical modeling and screening for prediction of molecular mechanisms of Simiao Pill against hyperuricemia

Q Chen, X Chen, X Chen, M Li, A Komori, X Sun… - Journal of Molecular …, 2023 - Elsevier
Hyperuricemia (HUA) is a type of purine metabolism disease and Simiao Pill (SMP), a
classic herbal prescription, has a long history of treating HUA. Nonetheless, the mechanisms …

[Retracted] A Network Pharmacology Method Combined with Molecular Docking Verification to Explore the Therapeutic Mechanisms Underlying Simiao Pill Herbal …

Y Qian, J Yin, J Ni, X Chen… - BioMed Research …, 2023 - Wiley Online Library
Objective. Hyperuricemia (HUA) is a common metabolic disease caused by disordered
purine metabolism. We aim to reveal the mechanisms underlying the anti‐HUA function of …

Exploring the therapeutic mechanism of Simiao pills for hyperuricemia based on network pharmacology and molecular docking

L Zeng, Y Deng, J Chen, X Sun, Y Liu… - … Fang yi ke da xue xue …, 2021 - europepmc.org
Objective To explore the mechanism of Simiao pills for treatment of hyperuricemia based on
network pharmacology and molecular docking. Objective The active ingredients of Simiao …

[HTML][HTML] Integrative computational approach for hyperuricemia treatment: 3D QSAR, molecular docking and dynamics of flavonoid analogues as xanthine oxidase …

D Navarro-Acosta, L Coba-Jiménez… - Journal of Molecular …, 2025 - Elsevier
Hyperuricemia is characterized by an excessive accumulation of uric acid in the joints, and
this condition remains a therapeutic challenge with limited options and significant side …

Potential molecular mechanisms of Ermiao san in the treatment of hyperuricemia and gout based on network pharmacology with molecular docking

YH Geng, JH Yan, L Han, Z Chen, SH Tu, LQ Zhang… - Medicine, 2022 - journals.lww.com
A network pharmacology integrated molecular docking strategy was used to predict the
underlying molecular mechanism of Ermiao san in the treatment of hyperuricemia and gout …

Discovery of Natural Multitarget Xanthine Oxidase Inhibitors for Therapeutic Hyperuricemia Using Virtual Screening, Network Pharmacology and in vitro …

L Cao, B Ma, B Yi, Y Liu, J Sun - ChemistrySelect, 2023 - Wiley Online Library
In this research, based on an important target xanthine dehydrogenase/oxidase (XDH/XO) of
therapeutical hyperuricemia, natural multitarget XO inhibitors are discovered from Chinese …

Xanthine oxidase targeted model setup and its application for antihyperuricemic compounds prediction by in silico methods

C Hou, C Shi, J Ren - EFood, 2021 - Wiley Online Library
To achieve potential alternatives for hyperuricemia therapeutics, a novel structure‐docking
energy relationship model was established for high‐throughput screening inhibitors of …

Hybridization of molecular docking studies with machine learning based QSAR model for prediction of xanthine oxidase activity

N Kumar, K Kaur, PMS Bedi - Computational and Theoretical Chemistry, 2023 - Elsevier
Xanthine Oxidase inhibitors treat hyperuricemia, but associated side effects have led
researchers to discover new inhibitors with fewer side effects. Our study employed a hybrid …

Wuling san based on network pharmacology and in vivo evidence against hyperuricemia via improving oxidative stress and inhibiting inflammation

J Huang, Z Lin, Y Wang, X Ding… - … Design, Development and …, 2023 - Taylor & Francis
Background Hyperuricemia (HUA) is a major public health issue with a high prevalence
worldwide. Wuling San (WLS) is an effective treatment for HUA. However, the active …

Mechanism of anti-hyperuricemia of isobavachin based on network pharmacology and molecular docking

J Luo, X Chen, P Liang, Z Zhao, T Wu, Z Li… - Computers in Biology …, 2023 - Elsevier
Background Hyperuricemia is a more popular metabolic disease caused by a disorder of
purine metabolism. Our previous study firstly screened out a natural product Isobavachin as …