Kynurenine (Kyn) is a tryptophan metabolite that increases with age and promotes
musculoskeletal dysfunction. We previously found a sexually dimorphic pattern in how Kyn …

Age‐dependent bone loss occurs in humans and in several animal species, including
rodents. The underlying causal mechanisms are probably multifactorial, although an age …

Context Studies in aged mice support a role for kynurenine, a tryptophan metabolite, in age-
induced bone loss; however, the role of kynurenine in human bone metabolism is not well …

The generation of reactive oxygen species increases with age and may play a pathogenic
role in the development of osteoporosis. We previously reported that kynurenine (kyn), the …

Aging is a progressive process associated with declining tissue function over time.
Kynurenine, an oxidized metabolite of the essential amino acid tryptophan that increases in …

There is increasing evidence of the involvement of the tryptophan metabolite kynurenine
(KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we …

Mechanisms leading to age-related reductions in bone formation and subsequent
osteoporosis are still incompletely understood. We recently demonstrated that kynurenine …

Osteoporosis is an age-related deterioration in bone health that is, at least in part, a stem
cell disease. The different mechanisms and signaling pathways that change with age and …

The diagnosis and treatment of bone disorders in patients with chronic kidney disease
(CKD) represent a clinical challenge. CKD leads to mineral and bone complications starting …

Background Reduced serum estrogen levels in postmenopausal patients not only aggravate
bone loss but also impact myokine secretion. Emerging evidence has revealed the …