Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

NN Parikshak, MJ Gandal, DH Geschwind - Nature Reviews Genetics, 2015 - nature.com
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Neuroscience in the era of functional genomics and systems biology

DH Geschwind, G Konopka - Nature, 2009 - nature.com
Advances in genetics and genomics have fuelled a revolution in discovery-based, or
hypothesis-generating, research that provides a powerful complement to the more directly …

Dissecting the molecular mechanisms of neurodegenerative diseases through network biology

JA Santiago, V Bottero, JA Potashkin - Frontiers in aging …, 2017 - frontiersin.org
Neurodegenerative diseases are rarely caused by a mutation in a single gene but rather
influenced by a combination of genetic, epigenetic and environmental factors. Emerging …

Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology

F Noorbakhsh, CM Overall, C Power - Trends in neurosciences, 2009 - cell.com
Classical biological methods involving analyses of one or several genes have been the
mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has …

Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease

J Bras, R Guerreiro, J Hardy - Nature Reviews Neuroscience, 2012 - nature.com
Over the past five years the field of neurogenetics has yielded a wealth of data that have
facilitated a much greater understanding of the aetiology of many neurological diseases …

Genetic changes shaping the human brain

BI Bae, D Jayaraman, CA Walsh - Developmental cell, 2015 - cell.com
The development and function of our brain are governed by a genetic blueprint, which
reflects dynamic changes over the history of evolution. Recent progress in genetics and …

Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility

CL Hartl, G Ramaswami, WG Pembroke, S Muller… - Nature …, 2021 - nature.com
Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

MR Johnson, K Shkura, SR Langley… - Nature …, 2016 - nature.com
Genetic determinants of cognition are poorly characterized, and their relationship to genes
that confer risk for neurodevelopmental disease is unclear. Here we performed a systems …

[HTML][HTML] Network medicine approaches to the genetics of complex diseases

EK Silverman, J Loscalzo - Discovery medicine, 2012 - ncbi.nlm.nih.gov
Complex diseases are caused by perturbations of biological networks. Genetic analysis
approaches focused on individual genetic determinants are unlikely to characterize the …

Systems biology and its application to the understanding of neurological diseases

P Villoslada, L Steinman… - Annals of Neurology …, 2009 - Wiley Online Library
Recent advances in molecular biology, neurobiology, genetics, and imaging have
demonstrated important insights about the nature of neurological diseases. However, a …