[HTML][HTML] Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms

YF Lin, CY Chen, D Öngür, R Betensky… - Translational …, 2018 - nature.com
Event-related potential (ERP) components have been used to assess cognitive functions in
patients with psychotic illness. Evidence suggests that among patients with psychosis there …

Psychotic-like experiences and polygenic liability in the adolescent brain cognitive development study

NR Karcher, SE Paul, EC Johnson, AS Hatoum… - Biological Psychiatry …, 2022 - Elsevier
Background Childhood psychotic-like experiences (PLEs) often precede the development of
later severe psychopathology. This study examined whether childhood PLEs are associated …

[HTML][HTML] Unraveling shared susceptibility loci and Mendelian genetic associations linking educational attainment with multiple neuropsychiatric disorders

D Chen, Y Zhou, Y Zhang, H Zeng, L Wu… - Frontiers in Psychiatry, 2024 - frontiersin.org
Background Empirical studies have demonstrated that educational attainment (EA) is
associated with neuropsychiatric disorders (NPDs), suggesting a shared etiological basis …

Genetic sources of subcomponents of event-related potential in the dimension of psychosis analyzed from the B-SNIP study

B Narayanan, LE Ethridge, K O'Neil… - American Journal of …, 2015 - Am Psychiatric Assoc
Objective: Biological risk factors underlying psychosis are poorly understood. Biological
underpinnings of the dimension of psychosis can be derived using genetic associations with …

General v. specific vulnerabilities: Polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study

MA Waszczuk, J Miao, AR Docherty… - Psychological …, 2023 - cambridge.org
Background Polygenic risk scores (PRSs) capture genetic vulnerability to psychiatric
conditions. However, PRSs are often associated with multiple mental health problems in …

[HTML][HTML] Genetic and clinical analyses of psychosis spectrum symptoms in a large multiethnic youth cohort reveal significant link with ADHD

LM Olde Loohuis, E Mennigen, APS Ori… - Translational …, 2021 - nature.com
Psychotic symptoms are not only an important feature of severe neuropsychiatric disorders,
but are also common in the general population, especially in youth. The genetic etiology of …

Combined polygenic risk scores of different psychiatric traits predict general and specific psychopathology in childhood

A Neumann, A Jolicoeur‐Martineau… - Journal of Child …, 2022 - Wiley Online Library
Background Polygenic risk scores (PRSs) operationalize genetic propensity toward a
particular mental disorder and hold promise as early predictors of psychopathology, but …

Not just one p: Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

TT Mallard, RK Linnér, A Okbay, AD Grotzinger… - BioRxiv, 2019 - biorxiv.org
A single dimension of general psychopathology, p, has been hypothesized to represent a
general liability that spans multiple types of psychiatric disorders and non-clinical variation …

Multivariate genome-wide analysis of education, socioeconomic status and brain phenome

FR Wendt, GA Pathak, T Lencz, JH Krystal… - Nature human …, 2021 - nature.com
Socioeconomic status (SES) and education (EDU) are phenotypically associated with
psychiatric disorders and behaviours. It remains unclear how these associations influence …

[HTML][HTML] Polygenic risk of mental disorders and subject-specific school grades

OH Jefsen, K Holde, JJ McGrath, VM Rajagopal… - Biological …, 2023 - Elsevier
Background Education is essential for socioeconomic security and long-term mental health;
however, mental disorders are often detrimental to the educational trajectory. Genetic …