Plant-produced potato virus X chimeric particles displaying an influenza virus-derived peptide activate specific CD8+ T cells in mice

C Lico, C Mancini, P Italiani, C Betti, D Boraschi… - Vaccine, 2009 - Elsevier
Plant viruses can be genetically modified to produce chimeric virus particles (CVPs) carrying
heterologous peptides. The efficacy of plant-produced CVPs in inducing antibody responses …

Immunogenic properties of chimeric potato virus X particles displaying the hepatitis C virus hypervariable region I peptide R9

K Uhde-Holzem, V Schlösser, S Viazov… - Journal of virological …, 2010 - Elsevier
The immunogenic properties of chimeric potato virus X (PVX) particles engineered to display
the synthetic R9 peptide have been evaluated. The R9 peptide is a consensus sequence …

Suitability of potyviral recombinant virus-like particles bearing a complete food allergen for immunotherapy vaccines

D Pazos-Castro, C Margain, Z Gonzalez-Klein… - Frontiers in …, 2022 - frontiersin.org
Virus-like particles (VLPs) have been gaining attention as potential platforms for delivery of
cargos in nanomedicine. Although animal viruses are largely selected due to their …

Use of plant viruses for production of plant-derived vaccines

LK Grill, KE Palmer, GP Pogue - Critical reviews in plant sciences, 2005 - Taylor & Francis
Plants produce appropriately folded, post-translationally processed proteins that, as
antigens, elicit efficacious immune responses in preclinical animal models and antigen …

Peptide display on Potato virus X: molecular features of the coat protein-fused peptide affecting cell-to-cell and phloem movement of chimeric virus particles

C Lico, F Capuano, G Renzone… - Journal of General …, 2006 - microbiologyresearch.org
The potexvirus Potato virus X (PVX) can be modified genetically to generate chimeric virus
particles (CVPs) carrying heterologous peptides fused to coat protein (CP) subunits. A …

Inactivation and purification of cowpea mosaic virus-like particles displaying peptide antigens from Bacillus anthracis

JP Phelps, N Dang, L Rasochova - Journal of virological methods, 2007 - Elsevier
Chimeric cowpea mosaic virus (CPMV) particles displaying foreign peptide antigens on the
particle surface are suitable for development of peptide-based vaccines. However …

The potential of plant virus vectors for vaccine production

V Yusibov, S Rabindran, U Commandeur, RM Twyman… - Drugs in R & D, 2006 - Springer
Plants viruses are versatile vectors that allow the rapid and convenient production of
recombinant proteins in plants. Compared with production systems based on transgenic …

Chimeric plant virus particles as immunogens for inducing murine and human immune responses against human immunodeficiency virus type 1

C Marusic, P Rizza, L Lattanzi, C Mancini… - Journal of …, 2001 - Am Soc Microbiol
The high-yield expression of a neutralizing epitope from human immunodeficiency virus type
1 (HIV-1) on the surface of a plant virus and its immunogenicity are presented. The highly …

Analysis of the ability of five adjuvants to enhance immune responses to a chimeric plant virus displaying an HIV-1 peptide

TL McInerney, FR Brennan, TD Jones, NJ Dimmock - Vaccine, 1999 - Elsevier
The ability of five different adjuvants (alum, complete Freund's adjuvant, Quil A, AdjuPrime
and Ribi) to stimulate humoral and T-cell mediated immune responses against a purified …

High-level systemic expression of conserved influenza epitope in plants on the surface of rod-shaped chimeric particles

NV Petukhova, TV Gasanova, PA Ivanov, JG Atabekov - Viruses, 2014 - mdpi.com
Recombinant viruses based on the cDNA copy of the tobacco mosaic virus (TMV) genome
carrying different versions of the conserved M2e epitope from influenza virus A cloned into …