Abstract Growth Factor Independence 1 (GFI1) is a transcriptional repressor that plays a
critical role during both myeloid and lymphoid haematopoietic lineage commitment. Several …

Differentiation of hematopoietic stem cells is regulated by a concert of different transcription
factors. Disturbed transcription factor function can be the basis of (pre) malignancies such as …

The differentiation of haematopoietic cells is regulated by a plethora of so-called
transcription factors (TFs). Mutations in genes encoding TFs or graded reduction in their …

Growth factor independence 1 (GFI1) is a DNA binding zinc finger protein, which can
mediate transcriptional repression mainly by recruiting histone-modifying enzymes to its …

The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation.
In the mouse, Gfi1 deficiency causes neutropenia and an accumulation of granulomonocytic …

Summary Growth factor independence 1 (GFI1) is a transcriptional repressor protein that
plays an essential role in the differentiation of myeloid and lymphoid progenitors. We and …

Genetic and epigenetic aberrations contribute to the initiation and progression of acute
myeloid leukemia (AML). GFI1, a zinc-finger transcriptional repressor, exerts its function by …

To investigate the molecular effects of growth factor independence 1B (Gfi-1B), a
transcription factor essential for the development of hematopoietic cells and differentiation of …

We identify a mutation (D262N) in the erythroid-affiliated transcriptional repressor GFI1B, in
an acute myeloid leukemia (AML) patient with antecedent myelodysplastic syndrome (MDS) …

Transcription factor Growth Factor Independence 1 (GFI1) regulates the expression of genes
important for survival, proliferation and differentiation of hematopoietic cells. A single …