The role of reactive iron in Alzheimer's Disease (AD) remains unresolved. Little is known of
how AD may alter iron transport, glutathione-mediated oxidative repair, and their …

Alzheimer's disease (AD) is an incurable dementia, with major risk factors being age and the
APOE-ε4 allele. AD has a hallmark neuropathology of neuronal death, lipid peroxidation …

Iron plays a crucial role in many physiological processes of the human body, but iron is
continuously deposited in the brain as we age. Early studies found iron overload is directly …

Iron is a fundamental metal involved in many cellular and biological processes in all
organisms, humans included. Iron homeostasis is finely regulated both systemically and at …

Objective This paper is a proposal for an update of the iron hypothesis of Alzheimer's
disease (AD), based on large‐scale emerging evidence. Background Iron featured …

Iron dyshomeostasis is implicated in Alzheimer's disease (AD) alongside β-amyloid and tau
pathologies. Despite the recent discovery of ferroptosis, an iron-dependent form cell death …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Iron is an essential trace element which mainly involves in the metabolism of
neurotransmitters and myelin formation in the nervous system. However, its high redox …

In the development of Alzheimer's disease (AD), cell death is common. Novel cell death form—
ferroptosis is discovered in recent years. Ferroptosis is an iron-regulated programmed cell …

Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …