PPARγ‐dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF)

AM Cimini, L Cristiano, S Colafarina… - … Journal of Cancer, 2005 - Wiley Online Library
Conjugated linoleic acid (CLA) has been shown to exert beneficial effects against
carcinogenesis, atherosclerosis and diabetes. It has been demonstrated that CLA modulates …

Involvement of PPARγ and E‐cadherin/β‐catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF‐7 cells

C Bocca, F Bozzo, S Francica… - … Journal of Cancer, 2007 - Wiley Online Library
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid, which has been shown to
exert beneficial effects against breast carcinogenesis. It has been reported that CLA could …

An overview of the effect of linoleic and conjugated‐linoleic acids on the growth of several human tumor cell lines

M Maggiora, M Bologna, MP Cerù… - … journal of cancer, 2004 - Wiley Online Library
Abstract Both n‐6 and n‐3 polyunsaturated fatty acids are dietary fats important for cell
function, being involved in several physiologic and pathologic processes, such as …

Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid

MF McCarty - Medical Hypotheses, 2000 - Elsevier
A number of human cancer cell lines express the PPARgamma transcription factor, and
agonists for PPARgamma are reported to promote apoptosis in these cell lines and impede …

Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARγ and APC/β-catenin pathways

F Bozzo, C Bocca, S Colombatto, A Miglietta - Chemico-biological …, 2007 - Elsevier
Conjugated linoleic acid (CLA), a naturally occurring substance in food sources, occurs as
mixtures of positional and geometrical isomers of octadecadienoate (18: 2), and may inhibit …

The influence of conjugated linoleic acid on the expression of peroxisome proliferator-activated receptor-γ and selected apoptotic genes in non-small cell lung cancer

BK Słowikowski, H Drzewiecka, M Malesza… - Molecular and cellular …, 2020 - Springer
In recent years, peroxisome proliferator-activated receptor-γ (PPARγ) has been intensively
studied. Because its activation is often associated with changes in the expression level of …

Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα

SY Moya-Camarena, JPV Heuvel, SG Blanchard… - Journal of lipid …, 1999 - ASBMB
We have previously shown that a mixture of dietary conjugated derivatives of linoleic acid
(conjugated linoleic acid, CLA) induces peroxisome proliferator-responsive enzymes and …

Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells

TD Shultz, BP Chew, WR Seaman, LO Luedecke - Cancer letters, 1992 - Elsevier
The effects of physiologic concentrations of conjugated linoleic acid (CLA) and β-carotene
were assessed on human (M21-HPB, malignant melanoma; HT-29, colorectal; MCF-7 …

Peroxisome proliferator activated receptor-γ (PPAR-γ) mediates the action of gamma linolenic acid in breast cancer cells

WG Jiang, A Redfern, RP Bryce, RE Mansel - … , Leukotrienes and Essential …, 2000 - Elsevier
Gamma linolenic acid (GLA) is a polyunsaturated fatty acid, which induces cytotoxicity and
regulates cell adhesion in cancer cells. The molecular mechanism of these actions is not …

Conjugated linoleic acid: implicated mechanisms related to cancer, atherosclerosis, and obesity.

MF Weiss, FA Martz, CL Lorenzen - 2004 - cabidigitallibrary.org
In a variety of experimental model systems, conjugated linoleic acids (CLA) are implicated
as anti-carcinogen, anti-atherosclerotic, and anti-inflammatory agents. The CLA is not a …