The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase that
plays a critical role in transcriptional silencing, genome stability, and longevity. A human …

Members of the evolutionarily conserved silent information regulator 2 (Sir2) protein family
are nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases. In yeast …

Aging is manifested by a progressive decline in vitality over time leading to death. Studies in
budding yeast allow aging to be followed in individual pedigrees of cells, that is, those of …

The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD‐dependent
histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate …

Sir2 is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase
involved in gene silencing and longevity. Cellular stresses affect Sir2 activity, but the …

Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones …

Under the condition of ADP-ribosylation reaction in vitro, NAD concentration is
approximately a few micromolar and the deacetylase activity of Sir2 is not detectable (Imai et …

SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor
Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in …

The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase
(HDAC) that functions in transcriptional silencing and longevity. The NAD+ salvage pathway …

The cellular NAD+/NADH level controls Sir2 (silent information regulator 2) deacetylase
activity in regulating aging in lower species. Much work has been put forth to identify ways to …