Functional properties of the neural cell adhesion molecule (NCAM) are strongly influenced
by polysialylation. We used gene-targeting to generate mice lacking ST8SiaIV/PST-1, one of …

The neural cell adhesion molecule (NCAM) and its post-translational modification polysialic
acid (polySia) are broadly implicated in neural development. Mice lacking the …

Polysialic acid (PSA) is a post-translational protein modification that is widely expressed
among neural cell types during development. Found predominantly on the neural cell …

Polysialic acid (polySia), a post-translational modification of the neural cell adhesion
molecule (NCAM), is the key regulator of NCAM-mediated functions and crucial for normal …

Polysialic acid, which is synthesized by two polysialyltransferases, ST8SiaII and ST8SiaIV,
plays an essential role in brain development by modifying the neural cell adhesion molecule …

The post-translational modification of the neural cell adhesion molecule (NCAM) by
polysialic acid (polySia) represents a remarkable example of dynamic modulation of homo …

Polymers of sialic acid can be produced by pro-and eukaryotic cells. In vertebrates polysialic
acid consists of α2, 8-linked N-acetylneuraminic acid and is most prominent during nervous …

Among the large set of cell surface glycan structures, the carbohydrate polymer polysialic
acid (polySia) plays an important role in vertebrate brain development and synaptic …

Poly-α2, 8-sialic acid (polySia) is a unique modification of the neural cell adhesion molecule,
NCAM, tightly associated with neural development and plasticity. However, the vital role …

Polysialic acid is a unique carbohydrate composed of a linear homopolymer of α2, 8-linked
sialic acid, and is mainly attached to the fifth immunoglobulin-like domain of the neural cell …