[HTML][HTML] A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications

JA Roche, R Roche - The FASEB Journal, 2020 - ncbi.nlm.nih.gov
Abstract As of April 20, 2020, over time, the COVID‐19 pandemic has resulted in 157 970
deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of~ 6.8%. With the …

Safety and outcomes associated with the pharmacological inhibition of the kinin–kallikrein system in severe COVID-19

E Mansour, AC Palma, RG Ulaf, LC Ribeiro… - Viruses, 2021 - mdpi.com
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …

[PDF][PDF] Kinins and cytokines in COVID-19: a comprehensive pathophysiological approach

F van de Veerdonk, MG Netea, M van Deuren… - 2020 - pdfs.semanticscholar.org
Most striking observations in COVID-19 patients are the hints on pulmonary edema (also
seen on CT scans as ground glass opacities), dry cough, fluid restrictions to prevent more …

Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID‐19

A Tabassum, MS Iqbal, S Sultan… - Mediators of …, 2022 - Wiley Online Library
The COVID‐19 pandemic is rapidly spreading, and health care systems are being
overwhelmed with the huge number of cases, with a good number of cases requiring …

A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases

DAB Rex, N Vaid, K Deepak, S Dagamajalu… - Molecular Biology …, 2022 - Springer
Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive
peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling …

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

FL van de Veerdonk, MG Netea, M van Deuren… - Elife, 2020 - elifesciences.org
COVID-19 patients can present with pulmonary edema early in disease. We propose that
this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) …

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

MR Garvin, C Alvarez, JI Miller, ET Prates, AM Walker… - elife, 2020 - elifesciences.org
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused over 9.2 million …

COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment

R Tolouian, SZ Vahed, S Ghiyasvand… - Journal of Renal Injury …, 2020 - journalrip.com
The novel coronavirus disease 2019 (COVID-19) is a rapidly expanding infection around the
world. The world Health Organization (WHO) in March 2020 announced the Coronavirus …

[HTML][HTML] A new storm on the horizon in COVID-19: Bradykinin-induced vascular complications

CG McCarthy, S Wilczynski, CF Wenceslau… - Vascular …, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) virus has taken an immeasurable toll on humanity, with the …