Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2)(known colloquially as COX-
2) were designed to minimize gastrointestinal complications of traditional NSAIDs—adverse …

Placebo-controlled trials of nonsteroidal antiinflammatory drugs (NSAIDs) selective for COX-
2 have revealed an enhanced risk for cardiovascular events. COX-2 inhibitors (coxibs) …

Selective inhibitors of cyclooxygenase (COX)-2 depress prostacyclin (PGI2) without a
concomitant inhibition of platelet COX-1-derived thromboxane (Tx) A2. Experiments in gene …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX),
which forms prostaglandins involved in pain and inflammation. COX inhibitors have …

Selective inhibitors of cyclooxygenase-2 (COX-2) were designed to minimize
gastrointestinal complications of traditional non-steroidal anti-inflammatory drugs (NSAIDs) …

Selective inhibitors of cyclooxygenase-2 (COX-2,'coxibs') are highly effective anti-
inflammatory and analgesic drugs that exert their action by preventing the formation of …

Selective inhibitors of cyclooxygenase (COX)-2 afford relief from pain and inflammation.
They could also prove useful in the chemoprevention of cancer and are being investigated …

Atherosclerosis is a process with inflammatory features and selective cyclooxygenase 2
(COX-2) inhibitors may potentially have antiatherogenic effects by virtue of inhibiting …

We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2
(PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and …

Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase (COX) enzymes,
which exist in at least two isoforms, COX-1 and COX-2. Aspirin and older agents in this class …