[HTML][HTML] Structural basis of receptor recognition by SARS-CoV-2

J Shang, G Ye, K Shi, Y Wan, C Luo, H Aihara, Q Geng… - Nature, 2020 - nature.com
A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently
emerged and is rapidly spreading in humans, causing COVID-19 1, 2. A key to tackling this …

Door to the cell for COVID-19 opened, leading way to therapies

Z Huang, J Chai - Signal Transduction and Targeted Therapy, 2020 - nature.com
A very recent study by Lan et al. 1 published in Nature determined the crystal structure of the
severe acute respiratory syndrome coronavirus (SARS-CoV)-2 receptor-binding domain …

[HTML][HTML] Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants

C Laffeber, K de Koning, R Kanaar… - Journal of molecular …, 2021 - Elsevier
Rapidly spreading new variants of SARS-CoV-2 carry multiple mutations in the viral spike
protein which attaches to the angiotensin converting enzyme 2 (ACE2) receptor on host …

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
A new and highly pathogenic coronavirus (severe acute respiratory syndrome coronavirus-
2, SARS-CoV-2) caused an outbreak in Wuhan city, Hubei province, China, starting from …

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

M Yuan, NC Wu, X Zhu, CCD Lee, RTY So, H Lv… - Science, 2020 - science.org
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently …

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

TN Starr, AJ Greaney, WW Hannon, AN Loes, K Hauser… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin …

Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant

W Zhang, K Shi, Q Geng, G Ye… - Proceedings of the …, 2022 - National Acad Sciences
The sudden emergence and rapid spread of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) omicron variant has raised questions about its animal …

Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA. 2.86 and JN. 1

H Yajima, Y Anraku, Y Kaku, KT Kimura… - Nature …, 2024 - nature.com
Abstract Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and
epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 …

Increased receptor affinity of SARS-CoV-2: a new immune escape mechanism

MF Bachmann, MO Mohsen, DE Speiser - npj Vaccines, 2022 - nature.com
Increased receptor affinity of SARS-CoV-2: a new immune escape mechanism | npj Vaccines
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New SARS-CoV-2 receptor

I Visan - Nature Immunology, 2023 - nature.com
SARS-CoV-2 has a broad tissue tropism. In Cell, Baggen et al. show that the lysosomal
transmembrane protein TMEM106B directly engages the receptor-binding domain (RBD) of …