We used magnetic resonance imaging and cortical matching algorithms to map gray matter
density (GMD) in 176 normal individuals ranging in age from 7 to 87 years. We found a …

We used high-resolution MRI to investigate gray and white matter aging in the major lobes of
the cerebrum (frontal, parietal, temporal, occipital) and the major sectors of the temporal lobe …

Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior,
cognition and the pathophysiology of several diseases, is crucial for establishing typical …

Patterns of gray matter (GM) loss were measured in 223 healthy subjects spanning eight
decades. We observed significant clusters of accelerated loss in focal regions of the frontal …

Prior studies have focused on patterns of brain atrophy with aging and age-associated
cognitive decline. It is possible that changes in neural tissue properties could provide an …

In this review, the authors summarize the literature on brain morphological changes that
occur throughout the human life span from childhood into old age. They examine changes …

Common risk factors for psychiatric and other brain disorders are likely to converge on
biological pathways influencing the development and maintenance of brain structure and …

Structural magnetic resonance imaging (MRI) studies have shown dramatic age-associated
changes in grey and white matter volume, but typically use univariate analyses that do not …

A pressing need exists to disentangle age-related changes from pathologic
neurodegeneration. This study aims to characterize the spatial pattern and age-related …

Age-related loss of brain tissue has been inferred from cross-sectional neuroimaging
studies, but direct measurements of gray and white matter changes from longitudinal studies …