The association of endoplasmic reticulum aminopeptidase 2 (ERAP2) with ankylosing
spondylitis (AS) was recently described in the large International Genetics of AS Consortium …

Objectives The functional interaction of endoplasmic reticulum aminopeptidase 1 (ERAP1)
with human leucocyte antigen (HLA)-B* 27 could be important in the pathogenesis of …

Objectives To assess whether there is excess transmission of alleles from the ERAP1
ERAP2 locus in families with ankylosing spondylitis (AS). Methods 199 multiplex families …

Objective A robust association between polymorphisms in the non-major histocompatibility
complex gene ERAP1 and ankylosing spondylitis (AS) in several populations was recently …

Objective Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase
1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key …

The mean annual incidence of AS also shows a direct correlation with the prevalence of
HLA-B27.[[3],[6]] HLA-B27 represents a family of closely related proteins encoded by an ever …

We investigated the proposal that ankylosing spondylitis (AS) is associated with unusual
ERAP1 genotypes. ERAP1 haplotypes were constructed for 213 AS cases and 46 …

ERAP1 in ankylosing spondylitis: genetics, biology and patho... : Current Opinion in
Rheumatology ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role …

Introduction Endoplasmic reticulum aminopeptidase-1 (ERAP1) protein is highly
polymorphic with numerous missense amino acid variants. We sought to determine the …

Abstract Purpose of Review We review our current knowledge about the clinical features of
patients with ankylosing spondylitis (AS) who possess HLA-B* 27 versus those who lack this …