In a prospective-longitudinal study of a representative birth cohort, we tested why stressful
experiences lead to depression in some people but not in others. A functional polymorphism …

Researchers are closely scrutinizing a gene that could explain why some people are
depressed—and also why they don't respond to antidepressant drugs that act on the …

Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and
anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown …

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been
implicated in anxiety in humans and animal models and is the site of action of widely used …

Research suggests that a polymorphism in the promoter region of the serotonin transporter
promoter (5-HTTLPR) interacts with stressful life events to predict depressive onset, with …

The distribution of 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the cerebrospinal
fluid of 68 depressed patients was bimodal. Twenty-nine percent of the patients were in the …

A functional polymorphism in the promoter region of the human serotonin transporter gene
(SLC6A4) has been associated with several dimensions of neuroticism and …

Several seemingly disconnected observations lie behind the idea that neurogenesis and
depression are linked. Stress, which suppresses neurogenesis, can also trigger bouts of …

The research team did note that the meta-analysis had some limitations. Recoding of the
data according to the methods used in the Caspi study may have led to findings different …