The challenge of modelling cancer presents a major opportunity to improve our ability to
reduce mortality from malignant neoplasms, improve treatments and meet the demands …

This paper outlines the major components and function of the technologically integrated
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …

The ContraCancrum project aims at developing a composite multilevel platform for
simulating malignant tumor development and tumor and normal tissue response to …

This paper presents a brief outline of the notion and the system of oncosimulator in
conjunction with a high level description of the basics of its core multiscale model simulating …

The development of computational models for simulating tumor growth and response to
treatment has gained significant momentum during the last few decades. At the dawn of the …

Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

The" Oncosimulator" is at the same time a concept of multilevel integrative cancer and
(treatment affected) normal tissue biology, an algorithmic construct and a software tool which …

Objectives Computational modeling of biological systems is a powerful tool to clarify diverse
processes contributing to cancer. The aim is to clarify the complex biochemical and …

Application of computer simulation for predicting cancer progression/remission/recurrence is
still underestimated by clinicians. This is mainly due to the lack of tumor modeling …

The multiscale complexity of cancer as a disease necessitates a corresponding multiscale
modelling approach to produce truly predictive mathematical models capable of improving …