In this chapter we operationalize familial risk for depression as having at least one parent
with a clinical diagnosis of depression during the child's lifetime. We briefly review the …

Major depressive disorder (MDD) is among the most prevalent, debilitating, and costly of all
illnesses worldwide. Investigators have made considerable progress in elucidating …

The Impact of Parental Depression on Offspring........................................... 444 Impact of
Parental Depression in Infants and Preschool-Aged Children …

BACKGROUND: Parental depression is associated with an increased risk of psychiatric
disorder in offspring, although outcomes vary. At present relatively little is known about how …

OBJECTIVE: To determine the differential effects of parental major depression (MDD) on
psychopathology of childhood, adolescent, and early-adult onset in offspring. METHOD: One …

In recent years, we have come to recognize the enormous toll that depression takes on
peoples' lives. In exploring the impact of this disorder, it has also become clear that …

Background. There is a large literature indicating that the offspring of mothers with Major
Depressive Disorder (MDD) are at increased risk for depression. However, much less is …

• The 2-year course, first onset (incidence), recurrence, and recovery of major depression in
174 offspring at high and low risk for major depression were studied. A variety of predictors …

Although the intergenerational transmission of risk for depression is well documented, the
mechanisms and moderators involved in this transmission of risk from depressed parents to …

Studying offspring of depressed mothers is a promising strategy for elucidating factors that
contribute to depression onset, given that these offspring are 3 to 6 times more likely to …