Long noncoding RNA ITPRIP-1 positively regulates the innate immune response through promotion of oligomerization and activation of MDA5

Q Xie, S Chen, R Tian, X Huang, R Deng, B Xue… - Journal of …, 2018 - Am Soc Microbiol
Emerging evidence indicates that long noncoding RNAs (lncRNAs) regulate various
biological processes, especially innate and adaptive immunity. However, the relationship …

Long noncoding RNA IFITM4P regulates host antiviral responses by acting as a competing endogenous RNA

M Xiao, Y Chen, S Wang, S Liu, KR Rai, B Chen… - Journal of …, 2021 - Am Soc Microbiol
Long noncoding RNAs (lncRNAs) are involved in numerous cellular processes. Increasing
evidence suggests that some lncRNAs function in immunity through various complex …

LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity

W Liu, Z Wang, L Liu, Z Yang, S Liu… - Proceedings of the …, 2020 - National Acad Sciences
Long noncoding RNAs (lncRNAs) involved in the regulation of antiviral innate immune
responses need to be further identified. By functionally screening the lncRNAs in …

MDA5 plays a critical role in interferon response during hepatitis C virus infection

X Cao, Q Ding, J Lu, W Tao, B Huang, Y Zhao, J Niu… - Journal of …, 2015 - Elsevier
Background & Aims Hepatitis C virus (HCV) is a human pathogen that can evade host
immunity to cause persistent infection, leading to liver cirrhosis and hepatocellular …

EFTUD2 is a novel innate immune regulator restricting hepatitis C virus infection through the RIG-I/MDA5 pathway

C Zhu, F Xiao, J Hong, K Wang, X Liu, D Cai… - Journal of …, 2015 - Am Soc Microbiol
The elongation factor Tu GTP binding domain-containing protein 2 (EFTUD2) was identified
as an anti-hepatitis C virus (HCV) host factor in our recent genome-wide small interfering …

lncRNAs regulate the innate immune response to viral infection

J Ouyang, J Hu, JL Chen - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are extensively expressed in mammalian cells and play a
crucial role as RNA regulators in various cellular processes. Increasing data reveal that they …

Hepatitis C virus NS5B triggers an MDA5‐mediated innate immune response by producing dsRNA without the replication of viral genomes

H Dansako, M Ikeda, Y Ariumi, Y Togashi… - The FEBS …, 2024 - Wiley Online Library
During the replication of viral genomes, RNA viruses produce double‐stranded RNA
(dsRNA), through the activity of their RNA‐dependent RNA polymerases (RdRps) as viral …

A long non-coding RNA IVRPIE promotes host antiviral immune responses through regulating interferon β1 and ISG expression

L Zhao, M Xia, K Wang, C Lai, H Fan, H Gu… - Frontiers in …, 2020 - frontiersin.org
Accumulating studies have shown that long non-coding RNAs (lncRNAs) modulate multiple
biological processes, including immune response. However, the underlying mechanisms of …

A human Long non-coding RNA LncATV promotes virus replication through restricting RIG-I–mediated innate immunity

J Fan, M Cheng, X Chi, X Liu, W Yang - Frontiers in immunology, 2019 - frontiersin.org
Pattern recognition receptors sense pathogen components and initiate the host antiviral
innate immune response, such as inducing interferons (IFNs). Long non-coding RNAs …

Long non-coding RNAs: regulators of viral infection and the interferon antiviral response

L Qiu, T Wang, Q Tang, G Li, P Wu, K Chen - Frontiers in microbiology, 2018 - frontiersin.org
Interferons (IFNs) are a family of cytokines providing a robust first line of host innate defense
against pathogenic infection, and have now been part of the standard treatment for viral …