Inhibition of Na+, K+-ATPase by ouabain triggers epithelial cell death independently of inversion of the [Na+] i/[K+] i ratio
D Pchejetski, S Taurin, S Der Sarkissian… - Biochemical and …, 2003 - Elsevier
Treatment with ouabain led to massive death of principal cells from collecting ducts (C7-
MDCK), indicated by cell swelling, loss of mitochondrial function, an irregular pattern of DNA …
MDCK), indicated by cell swelling, loss of mitochondrial function, an irregular pattern of DNA …
[Na+]i/[K+]i-independent death of ouabain-treated renal epithelial cells is not mediated by Na+,K+-ATPase internalization and de novo gene expression
OA Akimova, P Hamet, SN Orlov - Pflügers Archiv-European Journal of …, 2008 - Springer
The cytotoxic effect of long-term exposure of renal epithelial cells to ouabain and other
cardiotonic steroids (CTS) is mediated by the interaction of these compounds with Na+, K+ …
cardiotonic steroids (CTS) is mediated by the interaction of these compounds with Na+, K+ …
The death of ouabain-treated renal epithelial cells: evidence against anoikis occurrence
OA Akimova, M Poirier, SV Kotelevtsev, P Hamet… - Apoptosis, 2008 - Springer
The mechanisms of cell death signaling triggered by cardiotonic steroids are poorly
understood. Based on massive detachment of ouabain-treated Madin-Darby canine kidney …
understood. Based on massive detachment of ouabain-treated Madin-Darby canine kidney …
Death of ouabain-treated renal epithelial cells: evidence for p38 MAPK-mediated Na i + /K i + -independent …
OA Akimova, OD Lopina, AM Rubtsov, M Gekle… - Apoptosis, 2009 - Springer
Recent studies demonstrate that cytotoxic actions of ouabain and other cardiotonic steroids
(CTS) on renal epithelial cells (REC) are triggered by their interaction with the Na+, K+ …
(CTS) on renal epithelial cells (REC) are triggered by their interaction with the Na+, K+ …
Low doses of ouabain protect from serum deprivation–triggered apoptosis and stimulate kidney cell proliferation via activation of NF-κB
J Li, S Zelenin, A Aperia, O Aizman - Journal of the American …, 2006 - journals.lww.com
It now generally is agreed that Na, K-ATPase, in addition to its role in the maintenance of
Na+ and K+ gradients across the cell membrane, plays a role in communicating information …
Na+ and K+ gradients across the cell membrane, plays a role in communicating information …
Modest intracellular acidification suppresses death signaling in ouabain-treated cells
OA Akimova, D Pchejetski, P Hamet, SN Orlov - Pfluegers Archiv, 2006 - Springer
The signaling cascade resulting in the death of several types of cells treated with ouabain or
other cardiotonic steroids (CTS) remains poorly understood. Recently, we observed that …
other cardiotonic steroids (CTS) remains poorly understood. Recently, we observed that …
Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression
OD Lopina, AM Tverskoi, EA Klimanova… - Frontiers in …, 2020 - frontiersin.org
Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is
known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na …
known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na …
Na+/K+ pump and endothelial cell survival:[Na+] i/[K+] i-independent necrosis triggered by ouabain, and protection against apoptosis mediated by elevation of [Na+] i
SN Orlov, N Thorin-Trescases, D Pchejetski, S Taurin… - Pflügers Archiv, 2004 - Springer
Recent studies have demonstrated the tissue-specific effect of Na+/K+ pump inhibition by
ouabain and other cardiac glycosides on cell viability. The vascular endothelium is an initial …
ouabain and other cardiac glycosides on cell viability. The vascular endothelium is an initial …
Critical role of the α1-Na+, K+-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain
OA Akimova, AM Tverskoi, LV Smolyaninova… - Apoptosis, 2015 - Springer
In rodents, ubiquitous α1-Na+, K+-ATPase is inhibited by ouabain and other cardiotonic
steroids (CTS) at~ 10 3-fold higher concentrations than those effective in other mammals. To …
steroids (CTS) at~ 10 3-fold higher concentrations than those effective in other mammals. To …
Search for intermediates of Na+, K+-ATPase-mediated [Na+] i/[K+] i-independent death signaling triggered by cardiotonic steroids
OA Akimova, OD Lopina, P Hamet, SN Orlov - Pathophysiology, 2005 - Elsevier
Previously, we reported that ouabain and other cardiotonic steroids (CTS) kill renal epithelial
and vascular endothelial cells via their interaction with the Na+, K+-ATPase α-subunit, but …
and vascular endothelial cells via their interaction with the Na+, K+-ATPase α-subunit, but …