Targeted alternative splicing of TAF4: a new strategy for cell reprogramming
J Kazantseva, H Sadam, T Neuman, K Palm - Scientific Reports, 2016 - nature.com
Reprogramming of somatic cells has become a versatile tool for biomedical research and for
regenerative medicine. In the current study, we show that manipulating alternative splicing …
regenerative medicine. In the current study, we show that manipulating alternative splicing …
PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function
L Jobert, M Argentini, L Tora - Experimental cell research, 2009 - Elsevier
TAF15 (formerly TAFII68) is a nuclear RNA-binding protein that is associated with a distinct
population of TFIID and RNA polymerase II complexes. TAF15 harbours an N-terminal …
population of TFIID and RNA polymerase II complexes. TAF15 harbours an N-terminal …
Structural changes in TAF4b-TFIID correlate with promoter selectivity
WL Liu, RA Coleman, P Grob, DS King, L Florens… - Molecular cell, 2008 - cell.com
Proper ovarian development requires the cell type-specific transcription factor TAF4b, a
subunit of the core promoter recognition complex TFIID. We present the 35 Å structure of a …
subunit of the core promoter recognition complex TFIID. We present the 35 Å structure of a …
[HTML][HTML] Diversity in TAF proteomics: consequences for cellular differentiation and migration
J Kazantseva, K Palm - International Journal of Molecular Sciences, 2014 - mdpi.com
Development is a highly controlled process of cell proliferation and differentiation driven by
mechanisms of dynamic gene regulation. Specific DNA binding factors for establishing cell …
mechanisms of dynamic gene regulation. Specific DNA binding factors for establishing cell …
Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription
F El-Saafin, C Curry, T Ye, JM Garnier… - Human molecular …, 2018 - academic.oup.com
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP)
and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA …
and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA …
Alternative splicing targeting the hTAF4-TAFH domain of TAF4 represses proliferation and accelerates chondrogenic differentiation of human mesenchymal stem cells
J Kazantseva, A Kivil, K Tints, A Kazantseva… - PloS one, 2013 - journals.plos.org
Transcription factor IID (TFIID) activity can be regulated by cellular signals to specifically
alter transcription of particular subsets of genes. Alternative splicing of TFIID subunits is …
alter transcription of particular subsets of genes. Alternative splicing of TFIID subunits is …
TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival
E Scheer, J Luo, A Bernardini, F Ruffenach… - Journal of Biological …, 2021 - ASBMB
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP)
and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA …
and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA …
The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis
A Fadloun, D Kobi, JC Pointud, AK Indra, M Teletin… - 2007 - journals.biologists.com
The TAF4 subunit of transcription factor TFIID was inactivated in the basal keratinocytes of
foetal and adult mouse epidermis. Loss of TAF4 in the foetal epidermis results in reduced …
foetal and adult mouse epidermis. Loss of TAF4 in the foetal epidermis results in reduced …
AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation
D Uğurlu-Çimen, D Odluyurt, K Sevinç… - Epigenetics & …, 2021 - Springer
Background The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-
based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L …
based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L …
Targeting TBP-associated factors in ovarian cancer
JR Ribeiro, LA Lovasco, BC Vanderhyden… - Frontiers in …, 2014 - frontiersin.org
As ovarian tumors progress, they undergo a process of dedifferentiation, allowing adaptive
changes in growth and morphology that promote metastasis and chemoresistance. Herein …
changes in growth and morphology that promote metastasis and chemoresistance. Herein …