In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal
non-transcriptional functions in various biological processes critical for cellular homeostasis …
non-transcriptional functions in various biological processes critical for cellular homeostasis …
Characterization of the direct targets of FOXO transcription factors throughout evolution
FOXO transcription factors (FOXO s) are central regulators of lifespan across species, yet
they also have cell‐specific functions, including adult stem cell homeostasis and immune …
they also have cell‐specific functions, including adult stem cell homeostasis and immune …
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression
SKM Li, DK Smith, WY Leung, AMS Cheung… - Journal of Biological …, 2008 - ASBMB
The Forkhead box transcription factor FoxM1 is expressed in proliferating cells. When it was
depleted in mice and cell lines, cell cycle defects and chromosomal instability resulted …
depleted in mice and cell lines, cell cycle defects and chromosomal instability resulted …
FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
Aneuploidy, an abnormal chromosome number, has been linked to aging and age-
associated diseases, but the underlying molecular mechanisms remain unknown. Here we …
associated diseases, but the underlying molecular mechanisms remain unknown. Here we …
[HTML][HTML] Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related disease
K Hesp, G Smant, JE Kammenga - Experimental gerontology, 2015 - Elsevier
The insulin/IGF-1 signaling pathway is evolutionarily conserved and its function is mediated
largely by FOXO transcription factors. Reduced insulin/IGF-1 signaling leads to translocation …
largely by FOXO transcription factors. Reduced insulin/IGF-1 signaling leads to translocation …
Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila
FOXO transcription factors have long been associated with longevity control and tissue
homeostasis. Although the transcriptional regulation of FOXO have been previously …
homeostasis. Although the transcriptional regulation of FOXO have been previously …
FOXO3 and related transcription factors in development, aging, and exceptional longevity
AJ Kahn - Journals of Gerontology Series A: Biomedical …, 2015 - academic.oup.com
In June 2013, a workshop was convened in San Francisco to explore, in depth, the role of
the Forkhead transcription factor FOXO3 (and related FOXOs) in development, aging, and, in …
the Forkhead transcription factor FOXO3 (and related FOXOs) in development, aging, and, in …
Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice
A Durand, N Bonilla, T Level, Z Ginestet… - Nature …, 2024 - nature.com
Foxo family transcription factors are critically involved in multiple processes, such as
metabolism, quiescence, cell survival and cell differentiation. Although continuous, high …
metabolism, quiescence, cell survival and cell differentiation. Although continuous, high …
FOXO transcription factors at the interface between longevity and tumor suppression
A wide range of human diseases, including cancer, has a striking age-dependent onset.
However, the molecular mechanisms that connect aging and cancer are just beginning to be …
However, the molecular mechanisms that connect aging and cancer are just beginning to be …