People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of
developing kidney diseases through not fully understood mechanisms that impair the …

People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of
developing renal diseases. However, the mechanisms underlying APOL1-associated renal …

APOL1 harbors C–terminal sequence variants (G1 and G2), which account for much of the
increased risk for kidney disease in sub–Saharan African ancestry populations. Expression …

The apolipoprotein L1 (APOL1) gene is unique to humans and gorillas and appeared~ 33
million years ago. Since the majority of the mammals do not carry APOL1, it seems to be …

Coding variants in the APOL1 gene are associated with kidney diseases in African ancestral
populations; yet, the underlying biologic mechanisms remain uncertain. Variant-dependent …

APOL1 risk variants are associated with kidney disease in blacks, but the mechanisms of
renal injury associated with APOL1 risk variants are unknown. Because APOL1 is unique to …

African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …

Background Two coding renal risk variants (RRVs) of the APOL1 gene (G1 and G2) are
associated with large increases in CKD rates among populations of recent African descent …

Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans
has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To …

Two coding variants in the apolipoprotein L1 (APOL1) gene (termed G1 and G2) are strongly
associated with increased risk of nondiabetic kidney disease in people of recent African …