Pulmonary delivery of short interfering RNA (siRNA) has been widely studied in both animal
and clinical studies to treat various respiratory diseases by gene silencing through RNA …

The development of small interfering RNA (siRNA) formulation for pulmonary delivery is a
key to the clinical translation of siRNA therapeutics for the treatment of respiratory diseases …

Spray freeze drying is an attractive technology to produce powder formulation for inhalation.
It can be used to generate large porous particles which tend to aerosolize efficiently and do …

In order to evaluate the in vivo effect of inhaled formulations, it is a gold standard to create a
lung metastasis model by intravenously injecting cancer cells into an animal. Because the …

The therapeutic potential of small nucleic acids such as small interfering RNA (siRNA) to
treat lung diseases has been successfully demonstrated in many in vivo studies. A major …

Pulmonary delivery of small interfering RNAs (siRNAs) has shown promising results for the
treatment of lung diseases with gene disorders. The aim of this work was to evaluate the …

In the present study, a novel dry small interfering RNA (siRNA) powder for inhalation,
containing polyethyleneimine (PEI) as a delivery vector, was produced by spray freeze …

To develop stable and inhalable dry powder formulations with long shelf life, polyplexes
consisting of siRNA and a polyethylenimine (PEI)‐based block copolymer in presence of …

Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are
attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We …

This article reviews the pulmonary route of administration, aerosol delivery devices,
characterization of pulmonary drug delivery systems, and discusses the rationale for inhaled …