Inhibition of neocortical β-amyloid (Aβ) accumulation may be essential in an effective
therapeutic intervention for Alzheimer's disease (AD). Cu and Zn are enriched in Aβ deposits …

Metals such as zinc, copper and iron contribute to aggregation of amyloid-β (Aβ) protein and
deposition of amyloid plaques in Alzheimer's disease (AD). We examined whether the …

Alzheimer's disease (AD) is a neurodegenerative syndrom involving many different
biological parameters, including the accumulation of copper metal ions in Aβ amyloid …

Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels of
copper (Cu), the mechanism is not completely known. Cu could contribute to Aβ …

Cognitive decline in Alzheimer's disease (AD) involves pathological accumulation of
synaptotoxic amyloid-β (Aβ) oligomers and hyperphosphorylated tau. Because recent …

Background Alzheimer disease (AD) may be caused by the toxic accumulation of β-amyloid
(Aβ). Objective To test this theory, we developed a clinical intervention using clioquinol, a …

The key protein in Alzheimer's disease, the amyloid precursor protein (APP), is a
ubiquitously expressed copper-binding glycoprotein that gives rise to the Aβ amyloid …

The Cu-binding β-amyloid precursor protein (APP), and the amyloid Aβ peptide have been
proposed to play a role in physiological metal regulation. There is accumulating evidence of …

Abnormal interaction of β-amyloid 42 (Aβ42) with copper, zinc and iron induce peptide
aggregation and oxidation in Alzheimer's disease (AD). However, in health, Aβ degradation …

Besides targeting amyloid or tau metabolisms, regulation of redox metal ions is a recognized
therapeutic target for Alzheimer's disease (AD). Based on the bioinorganic chemistry of …