Background Huntington's disease (HD) is an autosomal dominant, fully penetrant,
neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to …

Background TRACK-HD is a prospective observational biomarker study in premanifest and
early Huntington's disease (HD). In this report we define a battery of potential outcome …

Background TRACK-HD is a prospective observational study of Huntington's disease (HD)
that examines disease progression in premanifest individuals carrying the mutant HTT gene …

Background TRACK-HD is a multinational prospective observational study of Huntington's
disease (HD) that examines clinical and biological findings of disease progression in …

Background Disease-modifying treatments are in development for Huntington's disease;
crucial to their success is to identify a timepoint in a patient's life when there is a measurable …

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …

There is growing consensus that intervention and treatment of Huntington disease (HD)
should occur at the earliest stage possible. Various early-intervention methods for this fatal …

TRACK‐HD is a multicentre longitudinal observational study investigating the use of clinical
assessments and 3‐Tesla magnetic resonance imaging as potential biomarkers for future …

Huntington's disease is an autosomal dominant, progressive neurodegenerative disorder,
for which there is no disease-modifying treatment. By use of predictive genetic testing, it is …

Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …