Background and aims Several epidemiological studies highlighted the association between
folate and B-vitamins low intake and cardiovascular diseases (CVD) risk. Contrasting results …

Background Elevated serum homocysteine is associated with an increased risk of
cardiovascular disease (CVD). This may reflect a reduced systemic remethylation capacity …

Background and aims DNA methylation of repetitive elements may explain the relations
between dietary intake, hyperhomocysteinemia, and cardiovascular disease risk. We …

Context: Folate pathway gene polymorphisms may be a risk factor for coronary artery
disease (CAD). However, studies of the association between these polymorphisms and CAD …

Background Sequence variants in genes functioning in folate-mediated one-carbon
metabolism are hypothesized to lead to changes in levels of homocysteine and DNA …

Results: Homocysteine was unrelated to CAD/MI (odds ratio (OR) 1.07 per log-transformed
sd, 95% confidence interval (CI) 0.96 to 1.19) based on 14 SNPs, as was folate (OR 1.18 per …

Aims Diet quality might influence cardiometabolic health through epigenetic changes, but
this has been little investigated in adults. Our aims were to identify cytosine–phosphate …

Background Folate and vitamin B-12 are essential micronutrients involved in the donation of
methyl groups in cellular metabolism. However, associations between intake of these …

The B vitamins are components of one-carbon metabolism (OCM) that contribute to DNA
synthesis and methylation. Homocysteine, a by-product of OCM, has been associated with …

A biomarker profile of high folate and vitamin B-12 and low plasma homocysteine
concentrations reduces the risk of coronary heart disease (CHD) and may be linked to diet …