Low muscle strength is an important heritable indicator of poor health linked to morbidity and
mortality in older people. In a genome-wide association study meta-analysis of 256,523 …

Decline in muscle strength with aging is an important predictor of health trajectory in the
elderly. Several factors, including genetics, are proposed contributors to variability in muscle …

The age-related decline in skeletal muscle mass, strength and function known as
'sarcopenia'is associated with multiple adverse health outcomes, including cardiovascular …

We performed a large genome-wide association study to discover genetic variation
associated with muscular strength, and to evaluate shared genetic aetiology with and causal …

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and
predictor of a range of morbidities and all-cause mortality. To investigate the genetic …

Across numerous model systems, aging skeletal muscle demonstrates an impaired
regenerative response when exposed to the same stimulus as young muscle. To better …

Western populations are living longer. Ageing decline in muscle mass and strength (ie
sarcopenia) is becoming a growing public health problem, as it contributes to the decreased …

Importance Muscle weakness is an important indicator of disability, chronic disease and
mortality. While we recently proposed sex/race specific grip strength cutpoints for clinical …

We here review the loss of muscle function and mass (sarcopenia) in the framework of
human healthspan and lifespan, and mechanisms involved in aging. The rapidly changing …

A variety of changes in skeletal muscle occur with aging. Sarcopenia is the age-associated
loss of muscle mass and is one of the main contributors to musculoskeletal impairments in …