The expansion of CGG repeats in the 5′-untranslated region (5′ UTR) of FMR1 gene is
the molecular basis of fragile X syndrome in most of the patients. The nature of the flanking …

Fragile X syndrome is one of 14 trinucleotide repeat diseases. It arises due to expansion of a
CGG repeat which is present in the 5′-untranslated region of the FMR1 gene, disruption of …

Fragile X syndrome is caused by an expansion of the CGG repeat present in the 5'UTR of
the FMR1 gene. A lot has been elucidated about the genetics of the disease, but not much is …

Expansion and methylation of CGG repeat sequences is associated with Fragile X syndrome
in humans. We have examined the consequences of CGG repeat expansion and …

The fragile X syndrome is characterized at the molecular level by expansion and methylation
of a CGG trinucleotide repeat located within the FMR1 locus. The tissues of most full …

Fragile X syndrome, the most common form of inherited mental retardation in males, arises
when the normally stable 5 to 50 CGG repeats in the 5′ untranslated region of the fragile X …

The fragile X syndrome is the most frequent cause of inherited mental retardation. The
molecular mechanism of the disorder is based on the expansion of a CGG repeat in the …

The Fragile X mental retardation gene (FMR1) contains a polymorphic trinucleotide CGG
repeat in the 5′ untranslated region (UTR) of the FMR1 messenger. We have characterized …

Methylation of CpG sequences in and around CGG triplet repeats in FMR1 gene has strong
correlation with manifestation of the fragile X syndrome in human patients. In contrast, we …

Fragile X syndrome (FXS) is characterized by moderate to severe intellectual disability,
which is accompanied by macroorchidism and distinct facial morphology. FXS is caused by …