Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila
The dysfunction of multiple neurotransmitter systems is a striking pathophysiological feature
of many mental disorders, schizophrenia in particular, but delineating the underlying …
of many mental disorders, schizophrenia in particular, but delineating the underlying …
Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice
JD Jentsch, H Trantham-Davidson, C Jairl… - …, 2009 - nature.com
Behavioral genetic studies of humans have associated variation in the DTNBP1 gene with
schizophrenia and its cognitive deficit phenotypes. The protein coded for by DTNBP1 …
schizophrenia and its cognitive deficit phenotypes. The protein coded for by DTNBP1 …
Dysbindin-1 and its protein family
Variation in the gene encoding dysbindin-1 (ie, dystrobrevin-binding protein 1: DTNBP1)
has frequently been associated with schizophrenia. Several studies have also found that …
has frequently been associated with schizophrenia. Several studies have also found that …
Role of dysbindin in dopamine receptor trafficking and cortical GABA function
Dysbindin has been implicated in the pathogenesis of schizophrenia, but little is known
about how dysbindin affects neuronal function in the circuitry underlying psychosis and …
about how dysbindin affects neuronal function in the circuitry underlying psychosis and …
Developmental genes and regulatory proteins, domains of cognitive impairment in schizophrenia spectrum psychosis and implications for antipsychotic drug discovery …
JL Waddington, X Zhen… - Frontiers in Pharmacology, 2020 - frontiersin.org
Alongside positive and negative symptomatology, deficits in working memory, attention,
selective learning processes, and executive function have been widely documented in …
selective learning processes, and executive function have been widely documented in …
Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia
YQ Feng, ZY Zhou, X He, H Wang, XL Guo… - Schizophrenia …, 2008 - Elsevier
Schizophrenia (SCZ) is a complex trait with a high heritability. The DTNBP1 gene (encoding
dysbindin) is one of the leading susceptible genes of SCZ. This risk gene has been reported …
dysbindin) is one of the leading susceptible genes of SCZ. This risk gene has been reported …
Dysbindin and Schizophrenia: it's dopamine and glutamate all over again
F Papaleo, DR Weinberger - Biological psychiatry, 2011 - biologicalpsychiatryjournal.com
Dysbindin-1 is encoded by the dystrobrevin-binding protein one gene (DTNBP1) and is
located in synaptic sites throughout human and mouse brain (1). Genetic variations in …
located in synaptic sites throughout human and mouse brain (1). Genetic variations in …
Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance
KH Karlsgodt, K Robleto, H Trantham-Davidson… - Biological …, 2011 - Elsevier
BACKGROUND:: Schizophrenia is a heritable disorder associated with disrupted neural
transmission and dysfunction of brain systems involved in higher cognition. The gene …
transmission and dysfunction of brain systems involved in higher cognition. The gene …
Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia
S Hattori, T Murotani, S Matsuzaki, T Ishizuka… - Biochemical and …, 2008 - Elsevier
Genetic susceptibility plays an important role in the pathogenesis of schizophrenia. Genetic
evidence for an association between the dysbindin-1 gene (DTNBP1: dystrobrevin binding …
evidence for an association between the dysbindin-1 gene (DTNBP1: dystrobrevin binding …
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
T Numakawa, Y Yagasaki, T Ishimoto… - Human molecular …, 2004 - academic.oup.com
Genetic variation in dysbindin (DTNBP1: dystrobrevin-binding protein 1) has recently been
shown to be associated with schizophrenia. The dysbindin gene is located at chromosome …
shown to be associated with schizophrenia. The dysbindin gene is located at chromosome …