Across healthy adult life our brains undergo gradual structural change in a pattern of atrophy
that resembles accelerated brain changes in Alzheimer's disease (AD). Here, using four …

Alzheimer's disease (AD) is associated with heterogeneous atrophy patterns,, which are
increasingly manifested throughout the disease course, driven by underlying …

Many of the Alzheimer's disease (AD) risk genes are specifically expressed in microglia and
astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD …

Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic
conditions of aging, including neurodegenerative and vascular disease. Because common …

Neuropathological changes associated with Alzheimer's disease (AD) can occur decades
before clinical symptoms. We investigated whether neurodevelopment and/or …

Alzheimer's disease (AD) has a slow onset, so it is challenging to distinguish brain changes
in healthy elderly persons from incipient AD. One-year brain changes with a distinct …

Brain aging is highly variable and represents a challenge to delimit aging from disease
processes. Moreover, genetic factors may influence both aging and disease. Here we …

Drugs developed to slow, halt or reverse the progression of Alzheimer's Disease (AD) have
failed to alter the course of the disease in clinical trials. One possible explanation is that …

Structural brain changes are commonly detectable on MRI before the progressive loss of
cognitive function that occurs in individuals with Alzheimer's disease and related dementias …

Introduction We examine whether distinct brain atrophy patterns (using brain parenchymal
fraction [BPF]) differentially predict functional performance and decline in Alzheimer's …