In the GRADE approach, the strength of a recommendation reflects the extent to which we
can be confident that the composite desirable effects of a management strategy outweigh …

This article describes the Grading of Recommendations Assessment, Development, and
Evaluation (GRADE) approach to classifying the direction and strength of recommendations …

GRADE requires guideline developers to make an overall rating of confidence in estimates
of effect (quality of evidence—high, moderate, low, or very low) for each important or critical …

Presenting continuous outcomes in Summary of Findings tables presents particular
challenges to interpretation. When each study uses the same outcome measure, and the …

Direct evidence comes from research that directly compares the interventions in which we
are interested when applied to the populations in which we are interested and measures …

This article is the first of a series providing guidance for use of the Grading of
Recommendations Assessment, Development, and Evaluation (GRADE) system of rating …

OBJECTIVES: In this article, we describe how to include considerations about resource
utilization when making recommendations according to the Grading of Recommendations …

GRADE requires a clear specification of the relevant setting, population, intervention, and
comparator. It also requires specification of all important outcomes—whether evidence from …

This article deals with inconsistency of relative (rather than absolute) treatment effects in
binary/dichotomous outcomes. A body of evidence is not rated up in quality if studies yield …

This article introduces the approach of GRADE to rating quality of evidence. GRADE
specifies four categories—high, moderate, low, and very low—that are applied to a body of …