Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution

F Heller, P Florian, C Bojarski, J Richter, M Christ… - Gastroenterology, 2005 - Elsevier
Background & Aims: Ulcerative colitis (UC) is characterized by a Th2 immune response with
inflammation and epithelial barrier dysfunction. So far, Th2 cytokines have not been shown …

[HTML][HTML] Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial …

F Heller, A Fromm, AH Gitter, J Mankertz… - Mucosal …, 2008 - Elsevier
In ulcerative colitis, the T helper type 2 proinflammatory cytokine Interleukin-13 (IL-13)
contributes as effector cytokine to the epithelial changes associated with disturbed epithelial …

Suppression of inflammation in ulcerative colitis by interferon-β-1a is accompanied by inhibition of IL-13 production

PJ Mannon, RL Hornung, Z Yang, C Yi, C Groden… - Gut, 2011 - gut.bmj.com
Objective Ulcerative colitis is associated with increased interleukin 13 (IL-13) production by
natural killer T cells. Taking advantage of the inhibitory actions of interferon β on IL-13 …

IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue

JM Leung, M Davenport, MJ Wolff, KE Wiens… - Mucosal …, 2014 - nature.com
T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in
maintaining mucosal barrier function and may be important in the pathogenesis of …

Absence of a role for interleukin‐13 in inflammatory bowel disease

P Biancheri, A Di Sabatino… - European journal of …, 2014 - Wiley Online Library
IL‐13 has been implicated in the pathogenesis of ulcerative colitis (UC), and may have a
role in animal models of gut fibrosis. We studied the involvement of IL‐13 in inflammation …

[HTML][HTML] Cytokines in the pathogenesis of ulcerative colitis

G Bamias, G Kaltsa, SD Ladas - Discovery medicine, 2011 - discoverymedicine.com
Ulcerative colitis is a chronic inflammatory condition of the large intestine whose etiology
remains largely unknown. Its pathogenesis involves the breakdown of intestinal mucosal …

IL-23/IL-17 immunity as a hallmark of Crohn's disease

V Hölttä, P Klemetti, T Sipponen… - Inflammatory bowel …, 2008 - academic.oup.com
Background We studied the balance between ileal T-effector cells versus T-regulatory cells
in active and inactive Crohn's disease (CD). Methods We compared effector and regulatory …

Characterization of cytokine expression in the rectal mucosa of ulcerative colitis: correlation with disease activity

S Inoue, T Matsumoto, M Iida, M Mizuno… - Official journal of the …, 1999 - journals.lww.com
OBJECTIVE: Mucosal inflammation in ulcerative colitis (UC) is presumed to be regulated by
Th2-like cytokines. The aim of this study was to characterize local expression of various …

Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis

S Melgar, MMW Yeung, A Bas… - Clinical & …, 2003 - academic.oup.com
Ulcerative colitis (UC), a chronic inflammatory bowel disease, exhibits pronounced increase
of T lymphocytes in the inflamed mucosa. To understand the role of intestinal T lymphocytes …

Increased numbers of interleukin-15-expressing cells in active ulcerative colitis.

I Kirman, OH Nielsen - American Journal of …, 1996 - search.ebscohost.com
Abstract Objectives: Interleukin-15 (IL-15) is a novel cytokine sharing many of the activities of
IL-2. The goal of this study was to evaluate intracellular and serum IL-15 in ulcerative colitis …