Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines

E Gottwein, DL Corcoran, N Mukherjee, RL Skalsky… - Cell host & …, 2011 - cell.com
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus
(KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV-and …

Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas

I Haecker, LA Gay, Y Yang, J Hu, AM Morse… - 2012 - journals.plos.org
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL),
and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded …

Kaposi's sarcoma-associated herpesvirus microRNAs

E Gottwein - Frontiers in microbiology, 2012 - frontiersin.org
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human pathogenic γ-herpesvirus
strongly associated with the development of Kaposi's Sarcoma and B cell proliferative …

Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155

RL Skalsky, MA Samols, KB Plaisance, IW Boss… - Journal of …, 2007 - Am Soc Microbiol
MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene
expression by binding to 3′-untranslated regions (3′ UTRs) of target mRNAs. Kaposi's …

KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways

R Moody, Y Zhu, Y Huang, X Cui, T Jones… - PLoS …, 2013 - journals.plos.org
Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several human
cancers, including Kaposi's sarcoma, primary effusion lymphoma and multicentric …

Pivotal advance: Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes

Z Qin, P Kearney, K Plaisance… - Journal of leukocyte …, 2010 - academic.oup.com
MicroRNA encoded by KSHV, a common tumor virus, induces macrophage secretion of
tumor-promoting cytokines by down-regulating the transcription factor C/EBPβ p20 isoform …

Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs

YT Lin, RP Kincaid, D Arasappan, SE Dowd… - Rna, 2010 - rnajournal.cshlp.org
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human tumor virus that encodes 12
precursor microRNAs (pre-miRNAs) that give rise to 17 different known∼ 22-nucleotide (nt) …

MicroRNAs encoded by Kaposi's sarcoma‐associated herpesvirus regulate viral life cycle

CC Lu, Z Li, CY Chu, J Feng, J Feng, R Sun… - EMBO …, 2010 - embopress.org
Kaposi's sarcoma‐associated herpesvirus (KSHV) is linked with Kaposi's sarcoma and
lymphomas. The pathogenesis of KSHV depends on the balance between two phases of the …

Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies

PE Chugh, SH Sin, S Ozgur, DH Henry… - PLoS …, 2013 - journals.plos.org
MicroRNAs (miRNAs) are stable, small non-coding RNAs that modulate many downstream
target genes. Recently, circulating miRNAs have been detected in various body fluids and …

In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machinery

JL Umbach, BR Cullen - Journal of virology, 2010 - Am Soc Microbiol
We have used deep sequencing to analyze the pattern of viral microRNA (miRNA)
expression observed in the B-cell line BC-3, which is latently infected with Kaposi's sarcoma …