Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination …

Y Furumatsu, Y Nagasawa, K Tomida, S Mikami… - Hypertension …, 2008 - nature.com
Although dual blockade of the renin-angiotensin-aldosterone system (RAAS) with the
combination of an angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin II …

Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial

L Tylicki, P Rutkowski, M Renke, W Larczyński… - American journal of …, 2008 - Elsevier
BACKGROUND: Agents inhibiting the renin-angiotensin-aldosterone (RAAS) system have
an important role in slowing the progression of chronic kidney disease. We evaluated the …

Double-blind, placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long …

A Chrysostomou, E Pedagogos… - Clinical journal of the …, 2006 - journals.lww.com
Studies have shown that dual therapy with angiotensin-converting enzyme inhibitors (ACEI)
and either angiotensin II receptor blockers or aldosterone receptor antagonists is more …

Dual blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy: the role of aldosterone

KJ Schjoedt, P Jacobsen, K Rossing… - Hormone and …, 2005 - thieme-connect.com
Dual blockade of the renin-angiotensin-aldosterone system (RAAS) with both ACE inhibitors
and angiotensin II receptor-blockers has been shown to reduce both albuminuria and blood …

Effects of additive therapy with spironolactone on proteinuria in diabetic patients already on ACE inhibitor or ARB therapy: results of a randomized, placebo-controlled …

MG Saklayen, LK Gyebi, J Tasosa… - Journal of Investigative …, 2008 - journals.sagepub.com
Introduction Aldosterone seems to have deleterious effects on the kidneys. Many animal
studies and a few clinical trials have shown that suppression of aldosteroneby aldosterone …

Dual blockade of the renin–angiotensin–aldosterone system: beyond the ACE inhibitor and angiotensin-II receptor blocker combination

AS Bomback, R Toto - American journal of hypertension, 2009 - academic.oup.com
The renin–angiotensin–aldosterone system (RAAS), an important regulator of blood
pressure as well as fluid and electrolyte balance, plays an important role in the …

Current status of dual renin angiotensin aldosterone system blockade for the treatment of cardiovascular diseases

SG Chrysant - The American journal of cardiology, 2010 - Elsevier
Clinical and experimental studies have shown that the initial suppression of angiotensin II
after the administration of angiotensin-converting enzyme (ACE) inhibitors is later reversed …

Efficacy and safety of combined vs. single renin–angiotensin–aldosterone system blockade in chronic kidney disease: a meta-analysis

P Susantitaphong, K Sewaralthahab… - American Journal of …, 2013 - academic.oup.com
BACKGROUND Although dual blockade of the renin–angiotensin–aldosterone system
(RAAS) has gained popularity for the treatment of kidney disease, its benefits and potential …

Effects of dual blockade of the renin angiotensin system in hypertensive type 2 diabetic patients with nephropathy.

JPS Matos, M de Lourdes Rodrigues… - Clinical …, 2005 - search.ebscohost.com
Aim: To evaluate the effects of combined treatment of an ACE inhibitor and an angiotensin II
receptor antagonist on parameters related to the progression of renal disease in type 2 …

Renal protection by inhibition of the renin-angiotensin-aldosterone system

T Berl - Journal of the Renin-Angiotensin-Aldosterone …, 2009 - journals.sagepub.com
Renin-angiotensin-aldosterone system (RAAS) inhibition exerts a renoprotective effect
independent of blood pressure reduction. Many studies using an end-point of proteinuria …