Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese
To fine map association signals of human leukocyte antigen (HLA) variants in the major
histocompatibility complex (MHC) region, we constructed a Japanese population-specific …
histocompatibility complex (MHC) region, we constructed a Japanese population-specific …
[HTML][HTML] Imputing amino acid polymorphisms in human leukocyte antigens
DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility
to a wide range of human diseases. The complex genetic structure of the major …
to a wide range of human diseases. The complex genetic structure of the major …
[HTML][HTML] HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases
Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
[HTML][HTML] High-accuracy imputation for HLA class I and II genes based on high-resolution SNP data of population-specific references
SS Khor, W Yang, M Kawashima, S Kamitsuji… - The …, 2015 - nature.com
Statistical imputation of classical human leukocyte antigen (HLA) alleles is becoming an
indispensable tool for fine-mappings of disease association signals from case–control …
indispensable tool for fine-mappings of disease association signals from case–control …
[HTML][HTML] Construction and application of a Korean reference panel for imputing classical alleles and amino acids of human leukocyte antigen genes
Genetic variations of human leukocyte antigen (HLA) genes within the major
histocompatibility complex (MHC) locus are strongly associated with disease susceptibility …
histocompatibility complex (MHC) locus are strongly associated with disease susceptibility …
Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles
F Degenhardt, M Wendorff, M Wittig… - Human molecular …, 2019 - academic.oup.com
Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means
to infer classical HLA alleles from inexpensive and dense SNP array data. In the research …
to infer classical HLA alleles from inexpensive and dense SNP array data. In the research …
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response
Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …
particularly in the MHC, which has population-specific structure. To enable such studies, we …
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
The genetic association of the major histocompatibility complex (MHC) to rheumatoid
arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate …
arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate …
Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population
To perform detailed fine-mapping of the major-histocompatibility-complex region, we
conducted next-generation sequencing (NGS)-based typing of the 33 human leukocyte …
conducted next-generation sequencing (NGS)-based typing of the 33 human leukocyte …
Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease
The human leukocyte antigen (HLA) locus is associated with more complex diseases than
any other locus in the human genome. In many diseases, HLA explains more heritability …
any other locus in the human genome. In many diseases, HLA explains more heritability …