Lung cancer ranks among the most common malignancies, and is the leading cause of
cancer-related mortality worldwide. Chemotherapy for lung cancer can be made more …

Chemotherapy is still the treatment of choice for many types of cancer; but its effectiveness is
hampered by dose limiting toxicity. Properly designed delivery systems can overcome this …

Lung cancer is the leading cause of cancer-related mortality worldwide. The lack of tumor
specificity remains a major drawback for effective chemotherapies and results in dose …

Although liposomes have improved patient safety and the pharmacokinetic profile of free
drugs, their therapeutic efficacy has only shown marginal improvement. The incorporation of …

Active targeting of the tumor microenvironment could be a helpful strategy to reduce toxicity
and drug resistance. Encapsulating anticancer agents in liposomes has improved tumor …

The therapeutic index of chemotherapeutic agents can be improved by the use of nano-
carrier-mediated chemotherapeutic delivery. Ligand-targeted drug delivery can be used to …

Purpose To investigate the correlation between the in vitro intracellular uptake and the in
vivo antitumor activity of anticancer drugs delivered by sterically stabilized liposomes (SSL) …

The clinical efficacy of the PEGylated doxorubicin liposomes (PLD) is limited by low tumor
accumulation and limited intra-tumoral disposition. Decoration with the cell penetration …

This study aimed to develop actively targeted liposomal formulations of doxorubicin (DOX)
using an engineered breast tumor targeting peptide ligand, p18-4 (WxEAAYQrFL). Towards …

In vivo evaluation of drug delivery vectors is essential for clinical translation. In BALB/c nude
mice bearing human breast cancer tumors, we investigated the biocompatibility …