Introduction: Chemokine receptors are important therapeutic targets for the treatment of
many human diseases. This study will provide an overview of approved chemokine receptor …

Chemokines are small basic proteins that are defined by the number and position of the
invariant cysteines in their protein sequence. 1 At the time this review was written more than …

Background: Chemokines were originally defined as host defense proteins, however, their
biological role goes well beyond this simple description of their function as immune cell …

The identification of chemokines and their receptors as potent mediators of leukocyte
infiltration raised interest in the potential role of these proteins on disease pathogenesis …

Background: The first part of this two-part review discussed approaches to generating
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …

Chemokine receptors have a key role in the pathogenesis of autoimmune diseases,
inflammation and viral infection. However, with the exception of selective CCR5 antagonists …

Chemokines and their receptors are central to the inflammatory process and are attractive
therapeutic targets. Drugs that inhibit chemokine receptors are approved for the treatment of …

Chemokines are a family of small chemoattractant cytokines that have an important role in
controlling leukocyte migration. The finding that some chemokines and their receptors are …

Chemokines are small cytokines that control a wide variety of biological and pathological
processes, from immunosurveillance to inflammation, and from viral infection to cancer. The …

Chemokines belong to a family of chemotactic cytokines that direct the migration of immune
cells towards sites of inflammation. They mediate their biological effects by binding to cell …