COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms

M Ostaszewski, A Niarakis, A Mazein… - Molecular systems …, 2021 - embopress.org
We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …

[HTML][HTML] COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms

M Ostaszewski, A Mazein, ME Gillespie, I Kuperstein… - Scientific data, 2020 - nature.com
COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host
interaction mechanisms | Scientific Data Skip to main content Thank you for visiting nature.com …

The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies

VP Waman, N Sen, M Varadi, A Daina… - Briefings in …, 2021 - academic.oup.com
SARS-CoV-2 is the causative agent of COVID-19, the ongoing global pandemic. It has
posed a worldwide challenge to human health as no effective treatment is currently …

Network for network concept offers new insights into host-SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs

N Eskandarzade, A Ghorbani, S Samarfard… - Computers in biology …, 2022 - Elsevier
Abstract SARS-CoV-2, the causal agent of COVID-19, is primarily a pulmonary virus that can
directly or indirectly infect several organs. Despite many studies carried out during the …

[HTML][HTML] COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection

F Messina, E Giombini, C Agrati, F Vairo… - Journal of translational …, 2020 - Springer
Background Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2
infection are under evaluation. A better understanding of the pathophysiology associated …

[HTML][HTML] Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections

A Ghavasieh, S Bontorin, O Artime… - Communications …, 2021 - nature.com
Protein–protein interaction networks have been used to investigate the influence of SARS-
CoV-2 viral proteins on the function of human cells, laying out a deeper understanding of …

Pathogenesis, symptomatology, and transmission of SARS-CoV-2 through analysis of viral genomics and structure

HM Rando, AL MacLean, AJ Lee, R Lordan, S Ray… - …, 2021 - Am Soc Microbiol
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around
the world and infected hundreds of millions of people with coronavirus disease 2019 …

Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research

F Hufsky, K Lamkiewicz, A Almeida… - Briefings in …, 2021 - academic.oup.com
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of
the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of …

[HTML][HTML] A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Y Zhou, Y Liu, S Gupta, MI Paramo, Y Hou, C Mao… - Nature …, 2023 - nature.com
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …

COVID-19 Knowledge Graph: a computable, multi-modal, cause-and-effect knowledge model of COVID-19 pathophysiology

D Domingo-Fernández, S Baksi, B Schultz… - …, 2021 - academic.oup.com
The COVID-19 crisis has elicited a global response by the scientific community that has led
to a burst of publications on the pathophysiology of the virus. However, without coordinated …