Fibrinogen binding to receptors on stimulated platelets is a prerequisite for platelet
aggregation. To gain further insight into the role of fibrinogen in platelet aggregation and to …

To define better the role of the fibrinogen receptor in platelet physiology and to characterize
it biochemically, a murine monoclonal antibody that completely blocks the binding of …

In summary: Incubation of platelets with ADP or proteolytic enzymes (chymotrypsin or
pronase) results in an exposure of two classes of specific binding sites on platelet surface …

Platelet aggregation requires the binding of fibrinogen to its receptor, a heterodimer
consisting of the plasma-membrane glycoproteins (GP) IIb and IIIa. Although the GPIIb-IIIa …

Several lines of evidence indicate that the platelet membrane glycoprotein IIb-IIIa complex
(GP IIb-IIIa) is necessary for the expression of platelet fibrinogen receptors. The purpose of …

Fibrinogen binding to receptors on stimulated platelets is a prerequisite for platelet
aggregation. In order to identify the platelet fibrinogen receptor, we modified fibrinogen with …

Platelet activation is accompanied by the appearance on the platelet surface of
approximately 45,000 receptor sites for fibrinogen. The binding of fibrinogen to these …

Specific receptors for fibrinogen can be induced on platelets by a variety of stimuli. In this
study, two independent approaches have implicated the D domain of fibrinogen in its …

Fibrinogen, a clottable plasma protein, agglutinates both prokaryotic cells (eg,
staphylococci) and eukaryotic cell fragments (eg, platelets) through interaction with specific …

The role of fibrinogen as a cofactor for platelet aggregation was examined by measuring the
binding of 125I-labeled human fibrinogen to gel-filtered human platelets both before and …